Back to Careers

Joyce James, PhD

linkedin-icon-green

Joyce James, Ph.D., is a strong leader with over twenty years of industry experience dedicated to the discovery and development of therapeutics, including small molecules, peptides, and biologics. Areas of expertise include nonclinical, early phase clinical trials, and bioanalytical, biomarker, and pharmacodynamic assays to support all stages of development, including related development and regulatory strategy. Founder of Corvid LLC, an early development and clinical pharmacology consulting company. Previously served as Vice President of Early Development and member of the management team for Odonate Therapeutics, an oncology-focused company. Founding and core member of Lyric Pharmaceuticals, serving as Vice President, Clinical Pharmacology & Early Development. Prior to Lyric, served as Senior Director and Head of Drug Metabolism and Pharmacokinetics & Analytical Chemistry at Cytokinetics, supporting numerous research and clinical programs. Held senior positions at Ambit Biosciences, playing a key role in the discovery and development of quizartinib for the treatment of FLT3-ITD positive acute myelogenous leukemia (approved in Japan). Provided critical support for the successful filing of multiple INDs and deep experience in nonclinical and clinical Phase 1 study designs. Consult for a number of biopharmaceutical companies providing ADME, analytical, clinical pharmacology, and bioanalytical support. Began a pharmaceutical career as a Research Fellow at Merck Research Labs, devoting time to both NMR spectroscopy and discovery DMPK. Ph.D. in Biophysical Chemistry, The University of California, Berkeley, Department of Chemistry and B.S. in Biochemistry, The College of Charleston, Department of Chemistry, summa cum laude.

Learn more about Joyce

LinkedIn

Back to Careers

Nicholas E. Johnson, MD, MSCI, FAAN

linkedin-icon-green

Nicholas E. Johnson, MD, MSCI, FAAN is an associate professor, division chief of neuromuscular, and vice chair of research in the department of neurology at Virginia Commonwealth University with a focus in inherited neuromuscular disorders. He received his undergraduate degree in molecular and cellular biology and psychology at the University of Arizona. He then obtained his medical degree at the University of Arizona. He completed his neurology residency and combined fellowship in neuromuscular medicine and experimental therapeutics at the University of Rochester. His laboratory is focused on identifying the pathogenesis of myotonic dystrophy, the limb girdle muscular dystrophies, and facioscapulohumeral muscular dystrophy and identifying appropriate clinical endpoints for these conditions. Johnson conducts therapeutic trials in many other inherited nerve and muscle disorders.

Research Expertise

Translational laboratory focused on identifying genetic modifiers across muscular dystrophies, and developing clinical endpoints and patient reported outcomes for myotonic dystrophy, facioscapulohumeral muscular dystrophy, and the limb girdle muscular dystrophy. The laboratory uses cellular models to identify changes in RNA splicing in myotonic dystrophy.

Learn more about Dr. Johnson

LinkedIn
VCU

Back to Careers

Tandis Vazin, PhD

linkedin-icon-green

The main objective of my scientific career has been to combine my studies in basic biology with innovative bioengineering approaches to find solutions to unmet challenges in biology and medicine. My academic training was primarily founded on stem cell engineering and gene therapy, with applications in regenerative medicine in the nervous system. After receiving my Ph.D. training in stem cell and cellular neurobiology at Johns Hopkins University and NIH, I joined Professor David Schaffer’s laboratory at UC Berkeley as a postdoctoral researcher. At UC Berkeley, by using a combination of advanced biological techniques including biomaterial systems and viral engineering, I made significant contributions to solving some of the critical challenges faced in cell and gene therapies for treatment of neurodegenerative disorders. Since completing my postdoctoral training and serving as a senior scientist at UC Berkeley, I have been an integral part of three cell and gene therapy-focused companies. I have successfully built scientific teams and departments to support proof-of-concept studies as well as IND-enabling work. At 4DMT, my department developed model systems for discovery and characterization of novel Adeno Associated Virus (AAV) variants with enhanced gene delivery efficiency and selectivity for treatment of retinal, muscle, lung, central nervous system (CNS), and liver monogenic and complex disorders. In this role, I provided scientific innovation and leadership in proof-of concept studies for multiple pipeline programs and platform improvement efforts progressing multiple products to IND-enabling studies and human clinical trials. At Ambys Medicines, I was responsible for establishing a gene therapy-focused department to develop therapeutics for treatment of severe liver disease and provided scientific innovation and leadership in various programs for liver cellular reprogramming and rejuvenation. I also served as the head of viral manufacturing. I am currently the CSO of Acrigen Biosciences and responsible for scientific development of technologies that can improve the efficiency and enhance the safety of CRISPR-Cas based gene editing.

Learn more about Tandis

PubMed Library
LinkedIn