Juvena’s diverse protein library and AI-enabled platform systematically maps secreted proteins to diseases and translates them into potent engineered biologic medicines.
The cells in our body secrete thousands of proteins, known collectively as the secretome. Proteins secreted by regenerative stem cells, in particular, have immense therapeutic potential. However, with over 4,000 secreted proteins and more than 70,000 recognized human diseases, identifying secreted proteins and translating them into engineered biologics remains a challenge with traditional methods.
Until now, the immense scale and complexity of investigating the curative potential of thousands of secreted proteins has limited the discovery of new therapeutics using traditional methods. The expansive diversity of Juvena’s proprietary protein library empowers our exploration of under-leveraged proteins. JuvNET is a first-of-its-kind platform that takes a fully integrated approach by combining in silico, in vitro, in vivo, and protein engineering techniques to translate the body’s natural secreted proteins into life-saving medicines.
Juvena combines our extensive regenerative protein library with the power of artificial intelligence (AI), quantitative proteomics, multi-omics, and robotics-enabled high-content imaging and screening to identify and develop novel disease-modifying biologics. Our multi-dimensional library reintegrates data with each cycle of drug screening to inform the therapeutic potential for new diseases and improve accuracy, cost-effectiveness, and speed.
The powerful approach of the JuvNET platform allows us to efficiently build a scalable pipeline of engineered biologics to enable transformative new medicines.
Our entire development pipeline consists solely of assets discovered and produced through our proprietary JuvNET platform, which we are independently advancing into clinical stages.
Explore our therapeutic pipeline bringing new possibilities to people living with muscular dystrophies and metabolic diseases.
The powerful approach of the JuvNET platform allows us to efficiently build a scalable pipeline of engineered biologics to enable transformative new medicines.
Our entire development pipeline consists solely of assets discovered and produced through our proprietary JuvNET platform, which we are independently advancing into clinical stages.
Explore our therapeutic pipeline bringing new possibilities to people living with muscular dystrophies and metabolic diseases.
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Secretome purification from multiple human pluripotent stem cell sources.
Protein function is determined.
Differentiating properties of each protein measured using quantitative proteomics.
Extensive first-in-class and expanding protein library of uniquely characterized therapeutic candidates.
AI modeling decodes protein characteristics and predicts functionality in diseases.
Laboratory assays verify target engagement in human phenotypic screening assays.
Leads are validated in vivo to confirm bioactivity and suitability for drug development.
Top secreted protein hits are engineered into biologics toward an indication-specific target product profile.