Decoding Secreted Proteins for Better Human Health

image depicting process of Juvena protein library moving through clinical translations to deliver tissue regeneration

Decoding Secreted Proteins for Better Human Health

Juvena Therapeutics is a venture-backed biopharma company unlocking the therapeutic potential of stem cell-secreted proteins and accelerating their development into life-saving therapies for multiple diseases.

We are achieving this through a machine learning-enhanced biologics drug discovery and development platform.

Secreted Proteins, Historically Difficult to Screen, are an Underleveraged Class of Biologics with Proven Therapeutic Potential

Secreted Proteins Communicate Naturally to Induce:

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Immune Response
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Repair Processes
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Stem Cell Activation
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Tissue Regeneration
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Advantages of Secreted Proteins

  • Natural signaling molecules
  • Highly specific to their targets
  • Evolved potency
  • Safer and more cost-effective than cell and gene therapies

Examples of Proteins Turned into Blockbuster Therapeutics

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Human pluripotent stem cell secretomes are enriched with proteins that modulate regeneration and inflammation with high therapeutic potential. (Kim et al. 2022, Yousef et al. 2013, 2011, 2014, Arnold Caplan 2017, Daneshmandi et al. 2020, Li et al. 2019, Kehl et al. 2019, Lopez-Verrilli et al. 2016, Phuong-Uyen et al. 2020)

Juvena’s Disruptive Platform Could Enable the Investigation of the Therapeutic Potential of Secreted Proteins in a Systematic Manner

Which protein could be the right treatment or target for any given disease when there are over 20,000 protein-coding genes in humans and over 70,000 recognized human diseases? This would lead to >1.4 Billion potential therapeutic mappings to test. 

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Despite the various successes that protein therapeutics have witnessed, secreted proteins have been underleveraged by the pharma industry. Underlying this is the challenge to applying computational and high-throughput screening techniques, which have been successful with small molecules, to protein drug discovery.

Juvena’s Computationally Driven Platform for Biologics Drug Discovery and Development

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Juvena’s machine learning-enhanced biologics drug discovery and development platform identifies lead therapeutic candidates from a proprietary pro-regenerative protein library to screen, validate, and engineer into tissue-specific medicines for degenerative diseases.

By testing machine learning-enabled therapeutic protein predictions with the innovative applications of quantitative proteomics, transcriptomics, and computer vision, we feed high-dimensional, multimodal data into a compounding database enabled by our growing human therapeutic protein library derived from mining the secretomes of human pluripotent stem cells.

Juvena’s Multi-Dimensional Library Accrues Compounding Data with Each Cycle of Drug Screening Informing Therapeutic Potential for New Indication

Juvena’s Multi-Dimensional Disease-Modifying Protein Library

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Patent Pending

The library that Juvena is curating is a multi-dimensional map of proteins and their diseases-modifying effects across different organs and indications. Combined with deep learning models, this library allows Juvena to identify and rank therapeutic candidates more cost-effectively and much quicker than traditional methods.