Priya Handa, PhD has over 20 years of experience in basic, preclinical and translational research spanning multiple disease areas including metabolic, hepatic, renal and ocular, among others. Prior to joining Juvena Therapeutics, Priya was a Principal Scientist and a team leader at Surrozen focused on tissue regeneration using their antibody platform in diseases with an unmet need. There, she championed several early stage discovery programs and was a key contributor to the Inflammatory Bowel Disease (IBD) program which is currently in Phase I clinical trials. Prior to joining Surrozen, Priya made seminal observations on the pathological underpinnings of nonalcoholic steatohepatitis( NASH) in the Swedish Organ Care Research Program and Benaroya Research Institute at Seattle working closely with world-renowned physician-scientist, Dr. Kris Kowdley. She published her pivotal findings in leading journals such as Hepatology, and presented over 30 posters and gave 7 podium talks in prestigious conferences such as American Association in the Studies on Liver Diseases (AASLD) and Digestive Diseases Week (DDW) among others, on her key work on liver diseases including Primary Sclerosing Cholangitis and Primary Biliary Sclerosis. Prior to that, at the University of Washington’s Diabetes Institute, Priya uncovered a central role for vascular nitric oxide signaling in regulating adipose tissue inflammation and metabolic dysfunction and highlighted an essential role for ApoA1 in regulating inflammation. She completed her Ph.D in the Indian Institute of Science delineating various DNA repair pathways, and received the best thesis award for her dissertation. She did her postdoctoral work at the University of Washington in Seattle on DNA repair and genomic instability. Priya has authored 38 publications including book chapters and reviews, and has presented her findings in numerous international meetings and is a co-inventor of a patent.
Dr. Li is a biologist with a multidisciplinary background in Biochemistry, Immunology, Cell and Molecular Biology, with 7 years of research experience in academia and 4 years in industry. He joined Juvena Therapeutics as a Protein Engineering Scientist to build protein expression and purification pipelines and to improve Juvena Therapeutics’ pipeline library of rejuvenating proteins for therapeutic purposes.
Following a BS in Biochemistry and Master’s Degree (MS) in genetics from scientific and technical universities in China, and a second MS in Molecular Microbiology and Immunology from the University of Southern California all during which he conducted research, Dr. Li completed his PhD (2007) and postdoctoral training (2014) in Cell and Molecular Biology from UT Austin, where he studied protein-protein interactions in different ways: first by combining computational predictions with experimental validations to discover 15 new protein factors functioning in the biogenesis of ribosomes; then by combining powerful mass spectrometry with protein fractionation techniques to create protein complex maps for both yeast and human cells. Continuing his exploration of novel protein interactions in his postdoctoral research, Dr. Li elucidated the self-cleavage mechanism of a novel membrane-bound transcription factor that drives oligodendrocyte differentiation. He’s published multiple co-authorships and first authorship studies along the way.
Before joining Juvena, Dr. Li worked in industry and biotech startups as Lead Scientist, Life Science Consultant, Scientific Advisor and R&D director. As Lead Scientist at BMLogic, Dr. Li developed and optimized the protein secretory production system in Pichia, leading to improved protein secretion efficiency and greatly reduced protein degradation.
Besides his passion for science, he enjoys spending time with his kid and exploring nature.
Trang joined Juvena Therapeutics as a Scientist to contribute to Dr. Li’s research on developing various assays for advancing Juvena Therapeutics’ pipeline library of rejuvenating proteins for therapeutic purposes.
Trang obtained her undergraduate degree in Biochemistry and Molecular Biology from UC Davis and continued to study for her Master in Immunology at UC Davis. Before joining Juvena, she worked at Teva Pharmaceuticals and worked extensively in their antibody screening. She managed an early antibody discovery project and had experiences in running various animal models for lead efficacy testing. She has extensive experience in flow cytometry, assay development and project leadership.
Han joined Juvena Therapeutics as a Research Associate to contribute to Dr. Li’s research on protein expression, purification pipelines, and to improve Juvena Therapeutics’ pipeline library of rejuvenating proteins for therapeutic purposes.
Han obtained his bachelor’s degree in biochemistry from the University of San Diego, with research areas focusing on exploring the enzymatic interactions of malate dehydrogenases and the utilization of defect-formations in the synthesis of metal-organic frameworks.
Before joining Juvena, Han worked as a Scientist III at the startup NovoNutrients for 4 years. He was heavily involved with the upstream and downstream process of gas fermentation using proprietary bioreactors and consortias. In addition to the fermentation work, he developed a novel synthetic biology platform to express high-value biomolecules ranging from enzymes, pharmaceuticals, to carotenoids in various consortia species. Later on, he took on the role of a strain engineer to develop a quick and reliable method to generate genomically-integrated strains of bacteria for industrial processes.
In Han’s free time, he enjoys playing the piano, hiking, and cycling around the Bay Area.