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Senior Program Manager – Preclinical & Platform

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Senior Program Manager – Preclinical & Platform who are excited to join a company focused on the discovery and validation of novel disease-modifying biologics that promote tissue regeneration by inducing tissue-specific rejuvenating phenotypes. We are discovering and developing various biologics that can promote disease-modifying phenotypes such as increased stem cell activity, reduced chronic or localized inflammation, reduced fibrosis, improved differentiation, or increased mitochondrial function and metabolism. 

The Senior Program Manager will lead the development, and be the hands-on project manager, of a portfolio of Discovery and Platform projects that are core to Juvena’s mission and strategy. Working with senior leadership and other stakeholders, the successful candidate will lead the development of integrated KPIs, R&D program plans, and portfolio management processes that provide a foundation for driving operational objectives, deliverables, execution, and timelines. They will lead and mentor the company on project management best practices while proactively driving weekly project objectives, identifying and analyzing dependencies, resource planning, determining impact of scenarios with priority changes and pivots on KPIs and milestone objectives, liaising with key stakeholders, and providing key status updates and recommendations to Senior Leadership.

The position is full-time starting as early as possible. This is the perfect opportunity for someone interested in the exciting and fast-paced environment of a startup company and looking to make a difference in human health and health-span.

*Title commensurate with experience

Company Summary

Juvena Therapeutics is a venture backed biotechnology startup discovering and developing disease-modifying biologics by leveraging their computationally-driven discovery platform to rapidly identify and validate secreted proteins with regenerative potential for multiple rare and chronic diseases.

At Juvena Therapeutics, we are on a mission to discover and develop biologics for rare and chronic degenerative diseases by mapping secreted proteins to unmet medical needs through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine the therapeutic potential of human stem cell secretomes as a rich source of new medicines that promote tissue regeneration and repair. We are advancing lead drug candidates for muscular dystrophies, atrophy, injury, and osteopathies, and establishing new programs targeting tissue-specific degenerative diseases across multiple therapeutic areas. Since our launch in mid-2018, Juvena has discovered and validated several hits for neuromuscular, skeletal, and metabolic diseases. Juvena’ preclinical programs are supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Position Location and work permit requirement

640 Galveston Dr. Redwood City, 64063

Candidate must be legally authorized to work in the US.

Position Requirements and Duties

  • Working with senior leadership and other stakeholders, lead the establishment of integrated KPIs, R&D program plans, and portfolio management processes that provide a foundation for driving operational objectives, deliverables, execution, and timelines. 
  • Drive program and project management processes & activities such as managing priority, scope, time, cost, risk, and quality while ensuring key company milestones & KPIs are defined and met. Manage meetings, including setting agendas, scheduling, and capturing meeting minutes.
  • Develop and directly manage project portfolio plans for a) the Discovery program through IND-filing for multiple Therapeutic Areas, and for b) the Platform program including Data Science/Bioinformatics/AI-ML projects.
  • Monitor ongoing projects for potential risks and develop proactive mitigation strategies with management and the relevant R&D teams. Identify, track, and support resolution efforts for all program-related issues and effectively communicate to relevant internal and external contractor teams via regular and ad-hoc status updates. 
  • Drive resource planning and impact analysis of priority change/pivot scenarios. Manage changes to project scope, ensuring that all impacts and changes are approved and appropriately communicated.
  • Liaise with external partners such as pharmaceutical companies and critical suppliers.
  • Support the development of TCPs (Target Candidate Profile) and initial TPPs (Target Product Profile).
  • Develop and maintain project/portfolio dashboards, reports, and metrics including timeline GANTTS and status summaries.
  • Lead and mentor the company on project management best practices adoption.
  • Other tasks as assigned.

Qualifications

This position is a great fit if you have/are:

  • Advanced degree + PMP certification (Scientific or Computational focused advanced degree is a plus)
  • 10+ years relevant experience in pharmaceutical drug discovery/development. Experience with biologics development is a plus.
  • 3+ years project management experience in pharmaceutical industry R&D.
  • Track record of advancing R&D projects though Discovery to developmental candidate nomination
  • Experience advancing through preclinical to IND filings a plus
  • ​​Ability to operate in a fast-paced, multi-disciplinary industrial environment.
  • Industry and startup R&D experience is a plus.
  • ​​Strong oral and written communication skills and meeting facilitation skills with the ability to work with others to achieve objectives.

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Senior Computational Biologist – Proteomics

Position Description

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Computational Biologist – Proteomics who are excited to work as a core member of a team focused on the discovery and validation of novel candidate biologics for tissue regeneration and increased stem cell activity.

The senior computational biologist will be responsible for driving lead biologics and biomarker discovery and prioritization from proteomics and multi-omics experiments by using their deep understanding of protein identification, quantitation,  and characterization, extracting meaningful biological insights from large, complex omics datasets (such as interaction networks, molecular single cell resolution studies, expression profiling), and integrating the results into Juvena Therapeutics’ growing in-house knowledge ecosystem. Expertise in protein modeling for computational chemistry/drug discovery would be considered equal to and in place of multi-omics analysis experience.

They will develop and apply creative, leading-edge approaches in bioinformatics, biostatistics, and machine-learning to identify novel biologics and enhance the efficiency of lead therapeutic drug screening and design. They will also support all stages of drug development that require proteomics applications and/or computational biology/bioinformatics.

The position is full-time starting as early as possible. This is the perfect opportunity for someone interested in the exciting and fast-paced environment of a startup company looking to make a difference in human health and healthspan.

Company Summary

Juvena Therapeutics is a venture backed biotechnology startup discovering and developing disease-modifying biologics by leveraging their computationally-driven discovery platform to rapidly identify and validate secreted proteins with regenerative potential for multiple rare and chronic diseases.

At Juvena Therapeutics, we are on a mission to discover and develop biologics for rare and chronic degenerative diseases by mapping secreted proteins to unmet medical needs through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine the therapeutic potential of human stem cell secretomes as a rich source of new medicines that promote tissue regeneration and repair. We are advancing lead drug candidates for muscular dystrophies, atrophy, injury, and osteopathies, and establishing new programs targeting tissue-specific degenerative diseases across multiple therapeutic areas. Since our launch in mid-2018, Juvena has discovered and validated several hits for neuromuscular, skeletal, and metabolic diseases. Juvena’ preclinical programs are supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Position Location and work permit requirement

640 Galveston Dr. Redwood City, 64063

Candidate must be legally authorized to work in the US.

Major Responsibilities

  • Bring to the Discovery team your expertise in:
    • Design and analysis of data-dependent acquisition  and data-independent acquisition proteomics experiments (mass-spec based required)
    • Analysis of isobaric labeling proteomics data
  • Integrate analysis of multi-omics and interaction network data or computational protein/drug discovery modeling
  • Reference and re-analyze existing proteomics datasets
  • Develop and apply machine learning methods to enhance the efficiency of candidate biologics discovery and screening for increased stem cell activity.
  • Work cross-functionally to create the best possible pipeline of candidate therapeutics and the tools to scale out efficiently across multiple indications. 
  • Improve efficiency by automating data extractions, analyses, and reporting; 
  • Other scientific tasks as required.
  • Actively survey the forefront of published methods and resources for your field and internalize key aspects to the company

Position Requirements and Experience

This position is a great fit if you have/are:

  • Ph.D. in bioinformatics, biology, biochemistry or analytical chemistry with 5+ years relevant experience in mass spectrometry-based proteomics 
  • Broad knowledge of mass spectrometry-based protein quantification and characterization strategies & analysis tools
  • Demonstrated mastery of bioinformatics/proteomics/multi-omics analysis with publications, co-inventorships, or other impressive achievements
  • Highly communicative. Effective communicator verbally, in writing, and in presentations to both expert and novice audiences
  • Self-Starter – Can work independently and/or collaboratively with scientists to make appropriate and timely decisions to meet deadlines on experiments and projects
  • Strong foundational knowledge and experience with biological data, particularly with methods generating large scale omics data sets (e.g. epigenomics, genomics, transcriptomics, proteomics)
  • Demonstrated expertise in an analysis and automation language (e.g. Python, R)
  • Demonstrated expertise in cloud computing systems – experience with Google Cloud and AWS resources is a plus
  • Familiarity with pharmaceutical R&D is a plus.
  • Industry or startup R&D experience is a plus.

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

This form is currently undergoing maintenance. Please try again later.

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Principal Data Scientist – Drug Discovery & Development

Position Description

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Principal Data Scientist – Drug Discovery & Development, who are excited to work as a core member of a team focused on the discovery and validation of novel candidate disease-modifying biologics that promote tissue regeneration by inducing tissue-specific rejuvenating phenotypes. We are discovering and developing various biologics that can promote disease-modifying phenotypes such as increasde stem cell activity, reduced chronic or localized inflammation, reduced fibrosis, improved differentiation, or increased mitochondrial function and metabolism.  

The Principal Data Scientist, reporting to the Head of Data Science and working closely with lab+computational scientists and other researchers, will drive the discovery and development of new therapeutic agents by providing leadership in statistical design, computational analysis, and predictive modeling throughout the drug discovery and development process, including algorithms for predicting disease-modifying biologic candidates & biomarkers, in vitro and in vivo experiment design and analysis, developing and automating assay read-out models & statistical QC analyses, and supporting regulatory approval (IND, NDA, etc.). The successful candidate will support pre-clinical and clinical activities related to regulatory interactions and approval as required. The Principal Data Scientist will also be a key contributor to Juvena Therapeutics’ growing in-house knowledge ecosystem (JuvNET), and developing tools and applications that extends to scientists the use JuvNET across organs, diseases, proteins, and pathways.

The position is full-time starting as early as possible. This is the perfect opportunity for someone interested in the exciting and fast-paced environment of a startup company looking to make a difference in human health and healthspan.

Company Summary

Juvena Therapeutics is a venture backed biotechnology startup discovering and developing disease-modifying biologics by leveraging their computationally-driven discovery platform to rapidly identify and validate secreted proteins with regenerative potential for multiple rare and chronic diseases.

At Juvena Therapeutics, we are on a mission to discover and develop biologics for rare and chronic degenerative diseases by mapping secreted proteins to unmet medical needs through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine the therapeutic potential of human stem cell secretomes as a rich source of new medicines that promote tissue regeneration and repair. We are advancing lead drug candidates for muscular dystrophies, atrophy, injury, and osteopathies, and establishing new programs targeting tissue-specific degenerative diseases across multiple therapeutic areas. Since our launch in mid-2018, Juvena has discovered and validated several hits for neuromuscular, skeletal, and metabolic diseases. Juvena’ preclinical programs are supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Major Responsibilities

  • Bring to the Juvena Team your expertise in:
    • statistical analysis and visualization of complex data relationships driving lead discovery and validation
    • statistical leadership in clinical & pre-clinical drug/biomarker development projects
    • Feature identification, algorithm development, and model selection approaches in the presence of potential bias, over-fitting, and other factors that impact generalizability of model performance
    • Establishing analytical pipelines, packages, & tools that drive best-practices and shared codebase development
  • Support pharmaceutical co-development projects and associated business development objectives
  • Support pre-clinical and clinical activities related to regulatory meetings and submissions
  • Develop and apply computational models to enhance the efficiency of candidate biologics identification, screening, and pre-clinical validation
  • Work cross-functionally to create the best possible pipeline of candidate therapeutics and the tools to scale out efficiently across multiple indications
  • Improve efficiency by automating data extractions, analyses, and reporting; 
  • Manage Google Cloud and AWS resources connected to relevant projects; 
  • Other tasks as required.
  • Actively survey the forefront of published methods and resources for your field and internalize key aspects to the company

Position Requirements and Experience

This position is a great fit if you have/are:

  • Ph.D in Biostatistics, Bioinformatics, a Biological field, or other related disciplines involving computational biological data analysis
  • 10+ years of experience applying computational & statistical analyses to Life Sciences R&D objectives such as biomarker discovery and development, early target discovery, pre-clinical & clinical study design, PK/PD, toxicogenomics, MOA studies, etc.
  • Demonstrated mastery of both computational-statistical analysis and biology with publications, co-inventorships, or other impressive achievements
  • Experience integrating and analyzing multi-omic data
  • Highly communicative – Effective communicator verbally, in writing, and in presentations to both expert and novice audiences
  • Highly motivated – loves working collaboratively with scientists, pursue delivering objective of analysis/tool to meet deadlines on experiments and projects
  • Demonstrated expertise in statistical computing language (e.g. R and/or Python)
  • Experience with cloud computing systems is a plus (e.g. GCP, AWS)
  • Industry and startup R&D experience is a plus

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Senior Research Associate/Associate Scientist

Bioanalytical Assay Development

Position Description

We are seeking a talented Senior Research Associate or Associate Scientist with experience in bioanalytical assay development to be an integral part of our drug discovery platform expansion. We are searching for an individual who is excited to perform bioanalytical assays in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases. Reporting to the Director of Protein Science, this individual will be an integral member of the expanding protein science team to increase our pipeline of state-of-the-art biologics. The ideal candidate will have industry experience in a drug discovery and early development setting and have been involved in lead candidate identification, selection, and IND-enabling studies for biologics.

Company Summary

Juvena Therapeutics is a venture backed biotechnology startup discovering and developing disease-modifying biologics by leveraging their computationally-driven discovery platform to rapidly identify and validate secreted proteins with regenerative potential for multiple rare and chronic diseases.

At Juvena Therapeutics, we are on a mission to discover and develop biologics for rare and chronic degenerative diseases by mapping secreted proteins to unmet medical needs through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine the therapeutic potential of human stem cell secretomes as a rich source of new medicines that promote tissue regeneration and repair. We are advancing lead drug candidates for muscular dystrophies, atrophy, injury, and osteopathies, and establishing new programs targeting tissue-specific degenerative diseases across multiple therapeutic areas. Since our launch in mid-2018, Juvena has discovered and validated several hits for neuromuscular, skeletal, and metabolic diseases. Juvena’ preclinical programs are supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Major Responsibilities

  • Develop, perform, and optimize bioanalytical assays for Juvena’s lead molecules
  • Conduct qualification and validation of bioanalytical assays following regulatory guidelines
  • Maintain accurate, timely, and detailed notebooks of all experimental work in accordance with SOPs
  • Assist in equipment purchase, maintenance, and calibration
  • Reagent sourcing, storage, inventory, preparation        
  • Communicate scientific data internally and externally
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation
  • Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows

Position Requirements and Experience

  • BS/MS degree in cell biology, molecular biology, biochemistry, or a related field with 2-5 years of industry experience in a drug discovery environment
  • Title and compensation commensurate with experience
  • Demonstrated ability to support biologic-based projects from lead generation to optimization, candidate selection, and IND filing 
  • Documented experience with bioanalytical assay development and troubleshooting

Preferred Qualifications

  • Experience with immunoassay development and statistical data analysis, such as ELISA, ADA assays, drug potency assays, and biomarker assays.
  • Experience with mammalian cell culture is preferred 
  • Knowledge of protein engineering, biophysical methods, and basic immunology
  • Strong organizational and communication skills
  • Detail oriented with a desire to obtain high quality data
  • Willingness to learn and enjoy working as a team

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

This form is currently undergoing maintenance. Please try again later.