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Vivarium Research Technician

Position Description

Juvena Therapeutics is seeking a highly motivated Vivarium Research Technician to join our dynamic research team in Redwood City, CA. This role will contribute to the growth of our research portfolio by supporting vivarium operations to advance the development of novel rejuvenating therapies. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment. The individual will report to Senior Scientist/Director in vivo Pharmacology.

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies, muscle atrophy, injury, and osteopathies. Since our launch in mid-2018, Juvena has discovered and validated 22 hits for neuromuscular, skeletal, and metabolic diseases. Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

Juvena Therapeutics has secured venture capital, NIH, and CIRM funding to develop their top lead to a clinical-stage investigational new drug, to build their stem cell secretome database, and to leverage their discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across inflammatory, cardiometabolic and hepatic therapeutic areas.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Company Location

640 Galveston Dr. Redwood City, 94063

Strong preference for onsite work at our office, but open to hybrid or remote working arrangements.

The candidate must be legally authorized to work in the U.S.

Major Responsibilities

• Support in vivo studies by performing rodent handling, dosing (PO, IV, IP, SC, RO, IM), interim and terminal blood collections, perfusion, anesthesia, necropsy and tissue collection.
• Perform tests such as grip strength, and/or other functional tests based on research needs.
• Collect and analyze data from these tests to support ongoing studies
• Perform routine animal husbandry such as cage changing, feeding, health observations, animal receipt, and basic health treatments.
• Comply with study protocols, vivarium policies and IACUC guidelines.
• Maintain accurate records for animal health reports, cage cards, etc.
• Maintain the highest standards of animal welfare.

 Position Requirements & Experience

• BA with 1-3+ years of relevant experience in a laboratory animal facility
• Must be able to work weekends
• Hands-on experience in handling, dosing, blood sampling, and tissue harvest in mice
• Must have a general understanding of animal welfare regulations and of the importance of ethical use of animals in research
• Strong attention to detail and ability to work independently with minimal guidance
• This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment

Preferred Qualifications

• Experience in industry set up
• AALAS certification is preferred

Compensation and Benefits

• Competitive salary, annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching 
• Pay Range: $60,000 – $80,000 yearly

Apply Now

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Scientist I – In Vivo Cardiometabolic & Muscle

Position Description

Juvena Therapeutics is seeking highly motivated in vivo Scientist to join the in vivo pharmacology team to support early preclinical validation of lead candidates. We are searching for a talented individual who is excited to work as a Scientist in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases across multiple therapeutic areas such as cardiometabolic, inflammation and muscle. The successful candidate should have extensive hands-on experience in surgeries, invasive and noninvasive imaging, including establishing, and characterizing pre-clinical cardiometabolic and inflammation models. The candidate should be able to design, execute & analyze in vivo efficacy studies independently. The scientific knowledge of the cardiometabolic, inflammation, & muscle-related areas is highly desired, as is the ability to present scientific data at in vivo and project-oriented  team meetings. The candidate will work collaboratively with various cross-functions within Juvena to support drug discovery projects with pharmacokinetic/pharmacodynamic (PK/PD) studies as well as efficacy and MOA studies. Reporting to the Director of Translational Biology and Pharmacology, this individual will be involved in validating diverse drug candidates in Juvena’s pipeline as well as supporting external R&D partnerships with academic institutions and technology providers.  

Company Summary

Juvena Therapeutics is a venture backed biotechnology startup discovering and developing disease-modifying biologics by leveraging their computationally-driven discovery platform to rapidly identify and validate secreted proteins with regenerative potential for multiple rare and chronic diseases.

At Juvena Therapeutics, we are on a mission to discover and develop biologics for rare and chronic degenerative diseases by mapping secreted proteins to unmet medical needs through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and high content imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine the therapeutic potential of human stem cell secretomes as a rich source of new medicines that promote tissue regeneration and repair. We are advancing lead drug candidates for muscular dystrophies, atrophy, injury, and osteopathies, and establishing new programs targeting tissue-specific degenerative diseases across metabolic related therapeutic areas. Since our launch in mid-2018, Juvena has discovered and validated several hits for neuromuscular, skeletal, and metabolic diseases. Juvena’ preclinical programs are supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Company Location

640 Galveston Dr. Redwood City, 94063

Major Responsibilities

• Lead efforts to expand Juvena’s in vivo pharmacology capabilities across multiple organ model systems to support growth of our biologics platform
• Work closely with the preclinical team members to design and execute in vivo experiments to support research and development of Juvena’s drug candidates for cardiometabolic, inflammation & muscle diseases
• Involved in in vivo model(s) development  including surgical models, & in vivo efficacy studies for cardiometabolic and muscle diseases to deliver high-quality results in a fast-paced setting
• Execute experiments following IACUC protocols, laboratory procedures, and safety standards
• Must be proficient in murine handling, dosing (PO, IV, IP, SC), survival and terminal blood collection (SM, tail nick, cardiac puncture), and tissue harvesting at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses        
• Experience in surgical skills for cardiometabolic models and imaging is required. Perform tissue processing for molecular, biochemical and histological analysis
• Carry out high throughput staining and image analysis
• Support IND-enabling studies for biologics, internally and externally via CRO project management across all phases of Juvena’s discovery and development
• Prepare presentations, technical reports, summaries, protocols
• Keep current with advances in the company’s area of research interest and lead journal club discussions of latest literature and research discoveries                    
• Contribute to a dynamic and exciting culture that embraces teamwork and innovation

Position Requirements and Experience

• M.S or Ph.D degree in biology, physiology, pharmacology or related field with 3+ years of industry experience (or equivalent). Post-doctoral experience is preferable, but not required.
• Surgical skills, and in vivo imaging experience is required. 
• Responsible for maintaining the highest standards of animal welfare and ethical compliance as well as data integrity
• Highly self-motivated, independent, and driven to succeed with strong interpersonal, communication and organization skills.
• Excellent hands-on in vivo skills 
• Can work with a diverse team in a highly collaborative growth environment with very strong communication 
• The ability to work effectively both independently and as part of multidisciplinary team in a fast-paced environment

Preferred Qualifications

• Documented experience in regenerative medicine
• Successful track record of indication selection and prioritization analyses 
• Understanding of how in vivo pharmacology data fits into bioinformatics and machine learning applications for drug discovery, target identification and disease model validation
• Direct experience in managing IND-enabling studies with significant contribution to FDA-approved INDs 
• Familiarity with pre-commercial process

Compensation and Benefits

• Competitive salary, annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching

Apply for the Position

Apply to this Job through the following means: 

• LinkedIn job posting
• Website job posting

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Research Associate (Intern)

Position Description

Juvena Therapeutics is seeking a highly self-motivated Research Associate intern with the option to become a full-time employee after 3 months. We are searching for an individual who is passionate about developing a multi-omics workflow that deeply interrogates the disease modifying effects of candidate molecules. The individual will be an integral member of the in vitro discovery team and will work alongside computational biologists and machine learning engineers.

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies and muscle atrophy, and validating hits across metabolic and pulmonary diseases with a goal to identify and develop two new assets in new disease indications over the next two years. Since our launch in mid-2018, Juvena has discovered dozens of hits for neuromuscular, skeletal, metabolic and pulmonary diseases, including several muscle regenerative protein therapeutic candidates with potent human in vitro and mice in vivo efficacy. Juvena is advancing a developmental candidate for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease, in IND-enabling studies. 

Juvena Therapeutics has secured venture capital, NIH, and CIRM funding to develop our top lead to a clinical-stage investigational new drug, to build our stem cell secretome database, and to leverage our discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across metabolic and pulmonary therapeutic areas. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Position Location and work permit requirement

640 Galveston Dr. Redwood City, 64063.

Candidates must be legally authorized to work in the US.

Major Responsibilities

• Development and optimization of functional genomics and high-content screening technologies
• Execution of NGS workflows including library prep and sequencing from cells and primary tissues
• Build our expertise in human disease models to expand Juvena’s platform screening capabilities across multiple organ model systems
• Integrate the latest in cell culture techniques and analytical methods to increase throughput and information content in our in vitro screening and pharmacology
• Perform experiments in disease model systems as well as support our projects with cell-based and biochemical assays
• Communicate scientific findings across different functional groups

Position Requirements and Experience

• A bachelor’s degree in biology, bioengineering, or a related field
• Experienced with troubleshooting technical challenges related to cell assays

Preferred Qualifications

• 1+ years of undergraduate or industry research experience in cell biology or genomics work
• Experienced in wet lab or dry lab workflows associated with cell culture, imaging, cloning, biochemistry, library preparation, and sequencing
• Experience with high content imaging, automation, or NGS pipelines
• Knowledge of regenerative medicine, adipose, or skeletal muscle biology  
• Experience with programming (Python preferred), especially in image, sequence, or data analysis

Compensation and Benefits

• Competitive salary and annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching

Apply for the Position

Apply to this Job through the following means: 

• LinkedIn job posting
• Website job posting

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Scientist, Protein Science

Position Description

Juvena Therapeutics is seeking a highly motivated scientist to join our growing Protein Science group, who will be an integral part of our drug discovery platform expansion to include new molecular scaffolds such as fusion proteins and other biologics. We are searching for an individual who is excited to work as a scientist in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel protein therapeutics for chronic and rare degenerative diseases. The Protein Science team is responsible for the lead identification, selection and optimization of therapeutic drug candidates with immense impact on cell and tissue regeneration. The ideal candidate will have expertise in cell culture, protein expression and purification as well as protein characterization assays. Reporting to the Director of Protein Science, the scientist will be a key part in growing our competencies and throughput in this team.

*Title commensurate with experience

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies, muscle atrophy, injury, and osteopathies. Since our launch in mid-2018, Juvena has discovered and validated 22 hits for neuromuscular, skeletal, and metabolic diseases. Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

Juvena Therapeutics has secured venture capital, NIH, and CIRM funding to develop their top lead to a clinical-stage investigational new drug, to build their stem cell secretome database, and to leverage their discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across inflammatory, cardiometabolic and hepatic therapeutic areas. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Company Location

640 Galveston Drive, Redwood City, CA, 94063

Major Responsibilities

• Primary project management of Contract Research Organization activities producing secreted proteins to support high-throughput screening.
• Coordinate the timely procurement, review, and execution of the Contract Research Organization agreements to conduct requisite development activities.
• Manage communication and activities among project leads for both internal and external groups to ensure milestone enabling activities are achieved on time and within budget.
• Advise on, institute, and enforce best practices for protein production and optimization.
• Develop and optimize upstream and downstream methods, including construct design, cell culture, protein expression, purification, and biophysical and biochemical characterization.
• Support early discovery and preclinical development by providing protein and analytical expertise to advance pipeline projects.
• Optimize the activity, stability, and pharmacokinetics of identified protein candidates by protein engineering to reach a desired target product profile.
• Present at group, company, and external meetings/conferences.
• Contribute to a dynamic and exciting culture that embraces teamwork and innovation.
• Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows.

Position Requirements and Experience

• Ph.D. in biochemistry, proteomics or other relevant applied biochemical science degree.
• 2+ years of postdoctoral or industry experience in applied biochemistry technologies to solve complex protein engineering and production problems.
• Experienced in wet lab and dry lab protein engineering and production workflows, and troubleshooting technical challenges related to the wet lab workflow and data analysis.
• Demonstrated an ability to support biologic-based high-throughput screening projects.
• Documented experience with QC assay development and troubleshooting.

Preferred Qualifications

• Previous experience with optimizing mammalian expression systems in a high throughput manner.
• A strong track record of research accomplishments in protein design and protein engineering.
• Familiar with one or more structural modeling programs such as Rosetta, MOE, Schrodinger, etc.
• Great attention to detail; competent critical thinking and troubleshooting, strong organizational skills; excellent communication skills.

Compensation and Benefits

• Salary range: $110,00 – $145,000 (commensurate with experience)
• Annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvena.mysites.io with the title of the position as the subject line.  

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Program Manager – Discovery, Platform, and G&A

Position Description

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Program Manager – Discovery, Platform, and G&A. Applicants should be excited to join a company focused on the discovery and validation of novel disease-modifying biologics that promote tissue regeneration by inducing tissue-specific rejuvenating phenotypes. 

This position (“the PM”) will report to the VP of Program Management and work closely with other Senior Leaders at Juvena daily. The PM will serve as the hands-on project manager of a broad portfolio of Discovery and Platform projects that are core to Juvena’s mission and strategy. Working with Leadership and other stakeholders, the successful candidate will work with the VP Program Management in the planning, execution, and control of integrated KPIs, Research, Discovery (R&D), and G&A program plans, and portfolio management processes that provide a foundation for driving operational objectives. The PM will train, coach, and mentor Staff and Leaders on project management best practices and proactively manage weekly project objectives, identify and analyze dependencies, perform resource planning, develop alternative scenarios based on priority changes and/or pivots on KPIs or objectives, liaise with key stakeholders, and provide regular status updates and recommendations to Leadership on projects within their portfolio.

The position is temporary with the option to convert to a regular full-time position with health benefits. This is the perfect opportunity for someone interested in the exciting and fast-paced environment of a startup company and looking to make a difference in improving people’s lives through science.

*Title commensurate with experience

Company Summary

Juvena Therapeutics is a venture backed biotechnology startup discovering and developing disease-modifying biologics by leveraging their computationally-driven discovery platform to rapidly identify and validate secreted proteins with regenerative potential for multiple rare and chronic diseases.

At Juvena Therapeutics, we are on a mission to discover and develop biologics for rare and chronic degenerative diseases by mapping secreted proteins to unmet medical needs through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine the therapeutic potential of human stem cell secretomes as a rich source of new medicines that promote tissue regeneration and repair. We are advancing lead drug candidates for muscular dystrophies, atrophy, injury, and osteopathies, and establishing new programs targeting tissue-specific degenerative diseases across multiple therapeutic areas. Since our launch in mid-2018, Juvena has discovered and validated several hits for neuromuscular, skeletal, and metabolic diseases. Juvena’ preclinical programs are supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Position Location and work permit requirement

640 Galveston Dr. Redwood City, 94063

Candidate must be legally authorized to work in the US.

Position Requirements and Duties

• Collaborate with the VP of Program Management to develop, promote, and support a foundation of project management best practices across Juvena by training, coaching, and mentoring Staff and Leaders in its adoption.
• Work with Leadership and other stakeholders to lead the establishment of integrated KPIs, R&D program plans, and portfolio management processes that provide a basis for driving operational objectives, deliverables, execution, and timelines.
• Drive program and project management processes and activities such as managing priorities, scope definition, schedules, budgets, risk, quality, and changes while ensuring key company milestones and KPIs are defined and met.
• Manage meetings in alignment with Juvena’s best practices (e.g., agenda and pre-read information provided, meeting outcomes pre-defined, logging of risks, action items, issues, and decisions [RAID log], etc.).
• Develop and manage portfolios for Platform and Discovery through pre-clinical readiness and Corporate G&A projects.
• Monitor ongoing projects for potential risks and develop proactive mitigation strategies with Leadership and the relevant R&D teams. Identify, track, and support resolution efforts for all program-related issues and effectively communicate to relevant internal and external contractor teams via regular and ad hoc status updates.
• For projects within their program, drive resource planning and impact analysis of priority change/pivot scenarios. Manage changes to project scope, ensuring that all impacts and changes are approved through Governance and appropriately communicated.
• Liaise with external partners such as pharmaceutical companies and critical suppliers.
• Support the development of TCPs (Target Candidate Profile) and initial TPPs (Target Product Profile).
• Develop and maintain project/portfolio dashboards, reports, and metrics including GANTT charts and status summaries.
• Other tasks as assigned.

Qualifications

You may be a great fit if you have the following qualifications:

• Basic Qualifications (required)
  • Undergraduate degree,
  • PMP certification,
  • Strong working knowledge of common project management best practices & tools (RAID logs, Gantt charts, Risk registers, etc.),
  • 2+ years project management experience in pharmaceutical drug discovery, development, or healthcare related R&D,
  • Ability to operate in a fast-paced, multi-disciplinary scientific environment that is often required to be adaptive and agile to respond to new discoveries and industry changes,
  • Strong oral and written communication, meeting facilitation, and organizational skills,
  • Ability to motivate, collaborate, and innovate to achieve objectives,
  • Ability to wear many hats with a team-first attitude.
• Bonus Qualifications (preferred)
  • Graduate degree, especially in a scientific or computational area,
  • 4+ years relevant experience in in pharmaceutical drug discovery, development, or healthcare related R&D,
  • Experience with biologics development,
  • Track record of advancing R&D projects through discovery to successful candidate nomination,
  • Experience advancing R&D projects through preclinical to successful IND or CTA regulatory filings,
  • Agile project management certification (CSM, PMI-ACP, etc.),
  • Industry and startup R&D experience.

Compensation

• Hourly rate: $70-$80 per hour, based on experience.

Apply Now

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with “Program Manager – Discovery & Platform” as the subject line.