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Clinical Development Project Manager 

Position Description

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Project Manager – Clinical Development. Applicants should be excited to join a company focused on the discovery and validation of novel disease-modifying biologics that promote tissue regeneration by inducing tissue-specific rejuvenating phenotypes. This position will report to the SVP of Drug Development and work closely with other Senior Leaders at Juvena. The PM will serve as the hands-on project manager of the research/development programs that are core to Juvena’s mission and strategy.

The Project Manager will play a key role in ensuring that our R&D initiatives are coordinated, appropriately timed, and efficient. Responsibilities include project planning, stakeholder management, resource and timeline tracking, and monitoring project performance. This position is ideal for an individual who thrives in a fast-paced collaborative environment with experience managing projects across multiple cross-functional scientific teams. The ideal candidate should have a strong background in biotech project management, particularly in pre-clinical/early clinical stages of development with IND and early clinical development directed goals.

*Title commensurate with experience 

Company Summary

Juvena Therapeutics is a venture-backed, clinical stage biotech company leveraging its AI-enabled platform to discover and advance tissue restorative biologics to tackle chronic muscle and metabolic diseases. The company’s approach stems from mapping the therapeutic potential of stem-cell secreted proteins and translating them into a growing pipeline of engineered biologics. Juvena is achieving this through a fully integrated, end-to-end AI-enabled platform, JuvNET, that combines a compounding database leveraging quantitative proteomics, multi-omics, high content imaging to map secreted proteins to specific disease phenotypes, utilizing in silico and in vitro human cell screening, pharmacology, and protein engineering capabilities. Juvena is progressing multiple preclinical programs, including a muscle regenerative biologic and a novel obesity asset with a unique mechanism. 

Juvena’s lead asset, JUV-161, is a muscle regenerating fusion protein with broad indication potential, currently in Phase 1 SAD clinical studies for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease. Juvena’s obesity candidate, JUV-112, is based on a novel secreted protein with an orthogonal, non-appetite suppressing MOA (non-GLP-1/GIP mediated) for improved fat metabolism, including insulin sensitivity and adipose regulation. Juvena is also identifying muscle targeting pro-metabolic and hypertrophic secreted proteins for Sarcopenic Obesity. Additionally, Juvena has discovered and validated 55+ hits across 6 therapeutic areas including fibrotic, hepatic, pulmonary, metabolic, osteopathies and inflammatory diseases. Juvena’s preclinical programs were supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena has raised about $60M to date and anticipates closing a $30M Series B and the kick-off of a discovery research collaboration with Eli Lilly in July 2025. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment. To learn more about Juvena Therapeutics, visit JuvenaTherapeutics.com or follow the company on LinkedIn @Juvena-Therapeutics.

Position Location and work permit requirement

640 Galveston Dr. Redwood City, 94063

Candidate must be legally authorized to work in the US.

Key Responsibilities

• Project Planning & Execution:
• Collaborate closely with the Project Lead and members of a cross-functional Project Team to develop detailed project plans, timelines, and resource allocations for program related initiatives.
• Support the cross-functional Project Team and any required team members to execute project deliverables on time and within scope.
• Coordinate Project Team meetings and track project milestones while promoting team accountability.
• Help to foster a collaborative and positive team environment to drive project success and achieve business objectives.
• Coordinate with stakeholders to establish clear project objectives, prioritize tasks, and manage costs effectively to help ensure project deliverables meet quality standards and are delivered on time and within budget.
• Ensure all key stakeholders are informed of progress, risks, and changes.
• Help the project team to identify topics and decisions that require escalation to the appropriate governance body and/or leadership forum, and coordinate of the review discussion
• Monitor project progress and identify and address any issues or risks that may impact project timelines or deliverables.
• Work with the cross-functional Project Team to develop contingency plans to address potential project roadblocks or delays.
• Monitor project budgets, ensuring costs are kept within approved limits.
• Coordinate with leadership and the Project Team on resource allocation and develop recommendations on optimizing resources.
• Assist with regulatory submissions and ensure all cross-functional project deliverables are provided on time and comply with relevant regulatory requirements (FDA, EMA, etc.).
• Provide regular updates and reports on project status, progress, and key metrics to senior leadership and cross-functional stakeholders.
• Promote, educate, and train leadership teams on industry standard project management best practices, and support the design and implementation of any necessary project management tools (e.g., trackers, etc.)

Position Qualifications

• Bachelor’s degree in life sciences, chemistry, biochemistry, or related field. An advanced degree (e.g., Ph.D., MBA) is a plus.
• 8+ years of project management experience in the biotech, pharmaceutical, or life sciences industries, with specific experience supporting early stage (IND-stage and Phase 1/2) programs
• Experience in startup environments is highly desirable.
• Strong organizational and multitasking skills with a proven track record of managing multiple complex projects simultaneously.
• Excellent communication and interpersonal skills for effectively liaising with both technical and non-technical stakeholders.
• Proficiency in project management tools (e.g., MS Project, Asana, etc.).
• Strong problem-solving skills with a proactive, can-do attitude.

Preferred Skills

• Familiarity with early-stage biotech operations, including R&D, clinical trials, or regulatory submissions.
• Knowledge of the biotech product development lifecycle, including regulatory requirements.
• PMP or equivalent project management certification is a plus but not required.
• Self-starter with the ability to adapt quickly to a dynamic and evolving environment.
• Passion for biotech and innovation, with an interest in driving meaningful impact through science.

Compensation

• Hourly rate: $125–$150 per hour, depending on experience. Also open to discussing a retainer structure in place of hourly billing.

Apply Now

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Vivarium Research Technician

Position Description

Juvena Therapeutics is seeking a highly motivated Vivarium Research Technician to join our dynamic research team in Redwood City, CA. This role will contribute to the growth of our research portfolio by supporting vivarium operations to advance the development of novel rejuvenating therapies. This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment. The individual will report to Senior Scientist/Director in vivo Pharmacology.

Company Summary

Juvena Therapeutics is a venture-backed, clinical stage biotech company leveraging its AI-enabled platform to discover and advance tissue restorative biologics to tackle chronic muscle and metabolic diseases. The company’s approach stems from mapping the therapeutic potential of stem-cell secreted proteins and translating them into a growing pipeline of engineered biologics. Juvena is achieving this through a fully integrated, end-to-end AI-enabled platform, JuvNET, that combines a compounding database leveraging quantitative proteomics, multi-omics, high content imaging to map secreted proteins to specific disease phenotypes, utilizing in silico and in vitro human cell screening, pharmacology, and protein engineering capabilities. Juvena is progressing multiple preclinical programs, including a muscle regenerative biologic and a novel obesity asset with a unique mechanism. 

Juvena’s lead asset, JUV-161, is a muscle regenerating fusion protein with broad indication potential, currently in Phase 1 SAD clinical studies for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease. Juvena’s obesity candidate, JUV-112, is based on a novel secreted protein with an orthogonal, non-appetite suppressing MOA (non-GLP-1/GIP mediated) for improved fat metabolism, including insulin sensitivity and adipose regulation. Juvena is also identifying muscle targeting pro-metabolic and hypertrophic secreted proteins for Sarcopenic Obesity. Additionally, Juvena has discovered and validated 55+ hits across 6 therapeutic areas including fibrotic, hepatic, pulmonary, metabolic, osteopathies and inflammatory diseases. Juvena’s preclinical programs were supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena has raised about $60M to date and anticipates closing a $30M Series B and the kick-off of a discovery research collaboration with Eli Lilly in July 2025. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment. To learn more about Juvena Therapeutics, visit JuvenaTherapeutics.com or follow the company on LinkedIn @Juvena-Therapeutics.

Company Location

640 Galveston Dr. Redwood City, 94063

Strong preference for onsite work at our office, but open to hybrid or remote working arrangements.

The candidate must be legally authorized to work in the U.S.

Major Responsibilities

• Support in vivo studies by performing rodent handling, dosing (PO, IV, IP, SC, RO, IM), interim and terminal blood collections, perfusion, anesthesia, necropsy and tissue collection.
• Perform tests such as grip strength, and/or other functional tests based on research needs.
• Collect and analyze data from these tests to support ongoing studies
• Perform routine animal husbandry such as cage changing, feeding, health observations, animal receipt, and basic health treatments.
• Comply with study protocols, vivarium policies and IACUC guidelines.
• Maintain accurate records for animal health reports, cage cards, etc.
• Maintain the highest standards of animal welfare.

 Position Requirements & Experience

• BA with 1-3+ years of relevant experience in a laboratory animal facility
• Must be able to work weekends
• Hands-on experience in handling, dosing, blood sampling, and tissue harvest in mice
• Must have a general understanding of animal welfare regulations and of the importance of ethical use of animals in research
• Strong attention to detail and ability to work independently with minimal guidance
• This position is ideal for a talented, highly motivated and results driven individual who will thrive in a fast-paced, innovative, start-up environment

Preferred Qualifications

• Experience in industry set up
• AALAS certification is preferred

Compensation and Benefits

• Competitive salary, annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching 
• Pay Range: $60,000 – $80,000 yearly

Apply Now

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Scientist I – In Vivo Cardiometabolic & Muscle

Position Description

Juvena Therapeutics is seeking highly motivated in vivo Scientist to join the in vivo pharmacology team to support early preclinical validation of lead candidates. We are searching for a talented individual who is excited to work as a Scientist in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases across multiple therapeutic areas such as cardiometabolic, inflammation and muscle. The successful candidate should have extensive hands-on experience in surgeries, invasive and noninvasive imaging, including establishing, and characterizing pre-clinical cardiometabolic and inflammation models. The candidate should be able to design, execute & analyze in vivo efficacy studies independently. The scientific knowledge of the cardiometabolic, inflammation, & muscle-related areas is highly desired, as is the ability to present scientific data at in vivo and project-oriented  team meetings. The candidate will work collaboratively with various cross-functions within Juvena to support drug discovery projects with pharmacokinetic/pharmacodynamic (PK/PD) studies as well as efficacy and MOA studies. Reporting to the Director of Translational Biology and Pharmacology, this individual will be involved in validating diverse drug candidates in Juvena’s pipeline as well as supporting external R&D partnerships with academic institutions and technology providers.  

Company Summary

Juvena Therapeutics is a venture-backed, clinical stage biotech company leveraging its AI-enabled platform to discover and advance tissue restorative biologics to tackle chronic muscle and metabolic diseases. The company’s approach stems from mapping the therapeutic potential of stem-cell secreted proteins and translating them into a growing pipeline of engineered biologics. Juvena is achieving this through a fully integrated, end-to-end AI-enabled platform, JuvNET, that combines a compounding database leveraging quantitative proteomics, multi-omics, high content imaging to map secreted proteins to specific disease phenotypes, utilizing in silico and in vitro human cell screening, pharmacology, and protein engineering capabilities. Juvena is progressing multiple preclinical programs, including a muscle regenerative biologic and a novel obesity asset with a unique mechanism. 

Juvena’s lead asset, JUV-161, is a muscle regenerating fusion protein with broad indication potential, currently in Phase 1 SAD clinical studies for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease. Juvena’s obesity candidate, JUV-112, is based on a novel secreted protein with an orthogonal, non-appetite suppressing MOA (non-GLP-1/GIP mediated) for improved fat metabolism, including insulin sensitivity and adipose regulation. Juvena is also identifying muscle targeting pro-metabolic and hypertrophic secreted proteins for Sarcopenic Obesity. Additionally, Juvena has discovered and validated 55+ hits across 6 therapeutic areas including fibrotic, hepatic, pulmonary, metabolic, osteopathies and inflammatory diseases. Juvena’s preclinical programs were supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena has raised about $60M to date and anticipates closing a $30M Series B and the kick-off of a discovery research collaboration with Eli Lilly in July 2025. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment. To learn more about Juvena Therapeutics, visit JuvenaTherapeutics.com or follow the company on LinkedIn @Juvena-Therapeutics.

Company Location

640 Galveston Dr. Redwood City, 94063

Major Responsibilities

• Lead efforts to expand Juvena’s in vivo pharmacology capabilities across multiple organ model systems to support growth of our biologics platform
• Work closely with the preclinical team members to design and execute in vivo experiments to support research and development of Juvena’s drug candidates for cardiometabolic, inflammation & muscle diseases
• Involved in in vivo model(s) development  including surgical models, & in vivo efficacy studies for cardiometabolic and muscle diseases to deliver high-quality results in a fast-paced setting
• Execute experiments following IACUC protocols, laboratory procedures, and safety standards
• Must be proficient in murine handling, dosing (PO, IV, IP, SC), survival and terminal blood collection (SM, tail nick, cardiac puncture), and tissue harvesting at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses        
• Experience in surgical skills for cardiometabolic models and imaging is required. Perform tissue processing for molecular, biochemical and histological analysis
• Carry out high throughput staining and image analysis
• Support IND-enabling studies for biologics, internally and externally via CRO project management across all phases of Juvena’s discovery and development
• Prepare presentations, technical reports, summaries, protocols
• Keep current with advances in the company’s area of research interest and lead journal club discussions of latest literature and research discoveries                    
• Contribute to a dynamic and exciting culture that embraces teamwork and innovation

Position Requirements and Experience

• M.S or Ph.D degree in biology, physiology, pharmacology or related field with 3+ years of industry experience (or equivalent). Post-doctoral experience is preferable, but not required.
• Surgical skills, and in vivo imaging experience is required. 
• Responsible for maintaining the highest standards of animal welfare and ethical compliance as well as data integrity
• Highly self-motivated, independent, and driven to succeed with strong interpersonal, communication and organization skills.
• Excellent hands-on in vivo skills 
• Can work with a diverse team in a highly collaborative growth environment with very strong communication 
• The ability to work effectively both independently and as part of multidisciplinary team in a fast-paced environment

Preferred Qualifications

• Documented experience in regenerative medicine
• Successful track record of indication selection and prioritization analyses 
• Understanding of how in vivo pharmacology data fits into bioinformatics and machine learning applications for drug discovery, target identification and disease model validation
• Direct experience in managing IND-enabling studies with significant contribution to FDA-approved INDs 
• Familiarity with pre-commercial process

Compensation and Benefits

• Competitive salary, annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching

Apply for the Position

Apply to this Job through the following means: 

• LinkedIn job posting
• Website job posting

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Research Associate (Intern)

Position Description

Juvena Therapeutics is seeking a highly self-motivated Research Associate intern with the option to become a full-time employee after 3 months. We are searching for an individual who is passionate about developing a multi-omics workflow that deeply interrogates the disease modifying effects of candidate molecules. The individual will be an integral member of the in vitro discovery team and will work alongside computational biologists and machine learning engineers.

Company Summary

Juvena Therapeutics is a venture-backed, clinical stage biotech company leveraging its AI-enabled platform to discover and advance tissue restorative biologics to tackle chronic muscle and metabolic diseases. The company’s approach stems from mapping the therapeutic potential of stem-cell secreted proteins and translating them into a growing pipeline of engineered biologics. Juvena is achieving this through a fully integrated, end-to-end AI-enabled platform, JuvNET, that combines a compounding database leveraging quantitative proteomics, multi-omics, high content imaging to map secreted proteins to specific disease phenotypes, utilizing in silico and in vitro human cell screening, pharmacology, and protein engineering capabilities. Juvena is progressing multiple preclinical programs, including a muscle regenerative biologic and a novel obesity asset with a unique mechanism. 

Juvena’s lead asset, JUV-161, is a muscle regenerating fusion protein with broad indication potential, currently in Phase 1 SAD clinical studies for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease. Juvena’s obesity candidate, JUV-112, is based on a novel secreted protein with an orthogonal, non-appetite suppressing MOA (non-GLP-1/GIP mediated) for improved fat metabolism, including insulin sensitivity and adipose regulation. Juvena is also identifying muscle targeting pro-metabolic and hypertrophic secreted proteins for Sarcopenic Obesity. Additionally, Juvena has discovered and validated 55+ hits across 6 therapeutic areas including fibrotic, hepatic, pulmonary, metabolic, osteopathies and inflammatory diseases. Juvena’s preclinical programs were supported by funding from the National Institute of Health (NIH) and the California Institute of Regenerative Medicine (CIRM). Juvena has raised about $60M to date and anticipates closing a $30M Series B and the kick-off of a discovery research collaboration with Eli Lilly in July 2025. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment. To learn more about Juvena Therapeutics, visit JuvenaTherapeutics.com or follow the company on LinkedIn @Juvena-Therapeutics.

Position Location and work permit requirement

640 Galveston Dr. Redwood City, 64063.

Candidates must be legally authorized to work in the US.

Major Responsibilities

• Development and optimization of functional genomics and high-content screening technologies
• Execution of NGS workflows including library prep and sequencing from cells and primary tissues
• Build our expertise in human disease models to expand Juvena’s platform screening capabilities across multiple organ model systems
• Integrate the latest in cell culture techniques and analytical methods to increase throughput and information content in our in vitro screening and pharmacology
• Perform experiments in disease model systems as well as support our projects with cell-based and biochemical assays
• Communicate scientific findings across different functional groups

Position Requirements and Experience

• A bachelor’s degree in biology, bioengineering, or a related field
• Experienced with troubleshooting technical challenges related to cell assays

Preferred Qualifications

• 1+ years of undergraduate or industry research experience in cell biology or genomics work
• Experienced in wet lab or dry lab workflows associated with cell culture, imaging, cloning, biochemistry, library preparation, and sequencing
• Experience with high content imaging, automation, or NGS pipelines
• Knowledge of regenerative medicine, adipose, or skeletal muscle biology  
• Experience with programming (Python preferred), especially in image, sequence, or data analysis

Compensation and Benefits

• Competitive salary and annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching

Apply for the Position

Apply to this Job through the following means: 

• LinkedIn job posting
• Website job posting

Please email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.

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Scientist, Protein Science

Position Description

Juvena Therapeutics is seeking a highly motivated scientist to join our growing Protein Science group, who will be an integral part of our drug discovery platform expansion to include new molecular scaffolds such as fusion proteins and other biologics. We are searching for an individual who is excited to work as a scientist in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel protein therapeutics for chronic and rare degenerative diseases. The Protein Science team is responsible for the lead identification, selection and optimization of therapeutic drug candidates with immense impact on cell and tissue regeneration. The ideal candidate will have expertise in cell culture, protein expression and purification as well as protein characterization assays. Reporting to the Director of Protein Science, the scientist will be a key part in growing our competencies and throughput in this team.

*Title commensurate with experience

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies, muscle atrophy, injury, and osteopathies. Since our launch in mid-2018, Juvena has discovered and validated 22 hits for neuromuscular, skeletal, and metabolic diseases. Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

Juvena Therapeutics has secured venture capital, NIH, and CIRM funding to develop their top lead to a clinical-stage investigational new drug, to build their stem cell secretome database, and to leverage their discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across inflammatory, cardiometabolic and hepatic therapeutic areas. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Company Location

640 Galveston Drive, Redwood City, CA, 94063

Major Responsibilities

• Primary project management of Contract Research Organization activities producing secreted proteins to support high-throughput screening.
• Coordinate the timely procurement, review, and execution of the Contract Research Organization agreements to conduct requisite development activities.
• Manage communication and activities among project leads for both internal and external groups to ensure milestone enabling activities are achieved on time and within budget.
• Advise on, institute, and enforce best practices for protein production and optimization.
• Develop and optimize upstream and downstream methods, including construct design, cell culture, protein expression, purification, and biophysical and biochemical characterization.
• Support early discovery and preclinical development by providing protein and analytical expertise to advance pipeline projects.
• Optimize the activity, stability, and pharmacokinetics of identified protein candidates by protein engineering to reach a desired target product profile.
• Present at group, company, and external meetings/conferences.
• Contribute to a dynamic and exciting culture that embraces teamwork and innovation.
• Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows.

Position Requirements and Experience

• Ph.D. in biochemistry, proteomics or other relevant applied biochemical science degree.
• 2+ years of postdoctoral or industry experience in applied biochemistry technologies to solve complex protein engineering and production problems.
• Experienced in wet lab and dry lab protein engineering and production workflows, and troubleshooting technical challenges related to the wet lab workflow and data analysis.
• Demonstrated an ability to support biologic-based high-throughput screening projects.
• Documented experience with QC assay development and troubleshooting.

Preferred Qualifications

• Previous experience with optimizing mammalian expression systems in a high throughput manner.
• A strong track record of research accomplishments in protein design and protein engineering.
• Familiar with one or more structural modeling programs such as Rosetta, MOE, Schrodinger, etc.
• Great attention to detail; competent critical thinking and troubleshooting, strong organizational skills; excellent communication skills.

Compensation and Benefits

• Salary range: $110,00 – $145,000 (commensurate with experience)
• Annual bonus and stock options
• Health/Dental/Vision insurance
• Paid vacation and holidays 
• Partial 401K matching

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvena.mysites.io with the title of the position as the subject line.