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Sr. Scientist/Scientist – In Vitro Pharmacology

Position Description

We are seeking a talented Scientist/Senior Scientist* to be an integral part of our drug discovery platform expansion to include disease model systems for emerging projects. We are searching for an individual who is excited to develop in vitro disease model systems in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases. Reporting to the Head of Discovery, the individual will be an integral member of the expanding discovery team to increase our pipeline of state-of-the-art biologics. The ideal candidate will have industry experience in a drug discovery and early development setting and have been involved in high throughput screening, lead candidate selection, and IND-enabling studies for biologics.

*Title commensurate with experience

Major Responsibilities

  • Build our expertise in human disease models to expand Juvena’s platform screening capabilities across multiple organ model systems
  • Integrate the latest in cell culture techniques and analytical methods to increase throughput and information content in our in vitro pharmacology
  • Oversee and perform experiments in disease model systems as well as support our projects with cell-based and biochemical assays
  • Work closely with our data science, pharmacology and protein engineering teams to further refine our drug discovery workflows              
  • Communicate scientific data internally and externally, authoring/reviewing study reports and regulatory documentation, contributing to high impact scientific manuscripts, identifying & managing external research collaborations                      
  • Guide and mentor the in vitro disease modeling team
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation
  • Keep current with clinical and scientific advances in the company’s therapeutic interest areas
  • Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows

Position Requirements and Experience

  • PhD in biochemistry, pharmacology or a related field with 2-5 years of industry experience in a drug discovery environment
  • Demonstrated ability to support biologic-based projects from lead generation to optimization, candidate selection, and IND
  • Documented experience with assay development and troubleshooting

Preferred Qualifications

  • Experience with 3D cultures and organoids
  • Familiarity with biologics such as proteins, fusion proteins, peptides, antibodies, and/or antibody drug conjugates
  • Knowledge of regenerative medicine, inflammation, and cardiometabolic disease areas 
  • Understanding of how disease model data fits into bioinformatics and machine learning applications

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Sr. Scientist/Scientist – In Vivo Pharmacology

Position Description

Juvena Therapeutics is seeking a talented pharmacologist who is excited to work as a scientist in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases across multiple therapeutic areas such as neuromuscular, inflammatory, hepatic, and metabolic-related diseases. This position would oversee the in vivo pharmacology efforts at Juvena with a particular focus on preclinical disease model studies. The ideal candidate will work closely with colleagues across data science, discovery, and clinical teams to expand Juvena’s platform for unraveling secretome biology to develop novel disease-modifying biologics. The ideal person will work collaboratively to establish robust disease model systems to support ongoing projects and validation of protein pharmaceutical drug candidates. Reporting to the Head of Discovery, the Senior Scientist in pharmacology will be involved in all of Juvena’s programs as well as overseeing external R&D partnerships with academic institutions and technology providers.

Major Responsibilities

  • Lead efforts to expand Juvena’s in vivo pharmacology capabilities across multiple organ model systems to support growth of our biologics platform
  • Work closely with the preclinical team members to design and execute in vivo experiments to support research and development of Juvena’s drug candidates for treatment of various rare and chronic degenerative diseases
  • Manage lab associates/scientists to deliver high-quality results in a fast-paced setting
  • Design and execute experiments following appropriate laboratory procedures and guidelines
  • Must be proficient in murine handling, dosing (PO, IV, IP, SC), survival and terminal blood collection (SM, tail nick, cardiac puncture), and tissue harvesting at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses       
  • Support IND-enabling studies for biologics, internally and externally via CRO project management across all phases of Juvena’s discovery and development
  • Carry out high throughput staining and image analysis
  • Prepare presentations, technical reports, summaries, protocols
  • Keep current with advances in the company’s area of research interest and lead journal club discussions of latest literature and research discoveries                   
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation

Position Requirements and Experience

  • PhD with 2+ years of industry experience (or equivalent) in a drug discovery and early development setting
  • Demonstrated ability to advance programs from discovery through lead identification and IND with biologics such as fusion proteins, bispecifics, antibody or antibody drug conjugates, preferably in the regenerative medicine space and/or inflammatory, cardiovascular, metabolic disease areas 
  • Experience interfacing with multiple key stakeholders in a dynamic environment to enable real-time prioritization
  • Strong communication skills
  • Prior success with research in a hands-on, highly collaborative growth environment

Preferred Qualifications

  • Documented experience in regenerative medicine
  • Successful track record of indication selection and prioritization analyses
  • Understanding of how in vivo pharmacology data fits into bioinformatics and machine learning applications for drug discovery, target identification and validation
  • Direct experience in managing IND-enabling studies with significant contribution to FDA-approved INDs
  • Familiarity with pre-commercial process

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Senior Research Associate – In Vitro Pharmacology

Position Description

We are seeking a talented Senior Research Associate to be an integral part of our drug discovery platform expansion to include disease model systems for emerging projects. We are searching for an individual who is excited to develop in vitro disease model systems in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases. The individual will be an integral member of the expanding discovery team to increase our pipeline of state-of-the-art biologics. The ideal candidate will have industry experience in a drug discovery and early development setting and have been involved in high throughput screening, lead candidate selection, and IND-enabling studies for biologics.

Major Responsibilities

  • Build our expertise in human disease models to expand Juvena’s platform screening capabilities across multiple organ model systems
  • Integrate the latest in cell culture techniques and analytical methods to increase throughput and information content in our in vitro pharmacology
  • Oversee and perform experiments in disease model systems as well as support our projects with cell-based and biochemical assays       
  • Communicate scientific data internally and externally
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation
  • Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows

Position Requirements and Experience

  • A relevant degree in biochemistry, pharmacology or a related field with 2-5 years of industry experience in a drug discovery environment
  • Demonstrated ability to support biologic-based projects from lead generation to optimization, candidate selection, and IND
  • Documented experience with assay development and troubleshooting

Preferred Qualifications

  • Experience with 3D cultures and organoids
  • Knowledge of regenerative medicine, inflammation, and cardiometabolic disease areas 
  • Understanding of how disease model data fits into bioinformatics and machine learning applications

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Scientist – Protein Science

Position Description

Juvena Therapeutics is seeking a highly motivated protein scientist to join us as our new Scientist of Protein Science, who will be an integral part of our drug discovery platform expansion to include new molecular scaffolds such as antibodies and other biologics. We are searching for an individual who is excited to work as a leader in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel protein therapeutics for chronic and rare degenerative diseases. The Protein Science team is responsible for the selection, design, and optimization of therapeutic drug candidates with immense impact on cell and tissue regeneration. The ideal candidate will have expertise in classical screening methodologies as well as computational protein design to increase our hit rates. Reporting to the Director of Protein Science, the Scientist will be a key part in growing our competencies and throughput in this team.

Key Responsibilities

  • Perform key steps in lead optimization process of promising hits from Juvena’s proprietary stem cell-derived protein library to identify candidates with great potential for drug development in various therapeutic areas
  • Optimize the activity, stability, and pharmacokinetics of identified protein candidates by amino acid and post-translational modification to reach a desired target product profile
  • Develop and optimize upstream and downstream methods, including protein expression, purification, and biophysical characterization
  • Support early discovery and preclinical development by providing protein and analytical expertise to advance pipeline projects
  • Present at group, company, and external meetings/conferences
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation
  • Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows

Job requirements

  • PhD in biochemistry or another relevant field with 0-5 years of experience (or equivalent experience in industry) with a preference for candidates that have previously worked with biologics drug discovery
  • Demonstrated ability to design, express and purify proteins in a high throughput manner in mammalian cell systems
  • Strong desire and initiative to understand the underlying technology and help propose new ideas and techniques to discover next-generation of protein-based therapeutics with unique functionalities
  • A strong track record of research accomplishments in protein design and protein engineering
  • Excellent communication and technical writing skills
  • Ability to work effectively with others in a dynamic environment

Preferred Qualifications

  • Previous experience with optimizing mammalian expression systems
  • Experience with protein variant structure-activity relationships
  • Familiar with one or more structural modeling programs such as Rosetta, MOE, Schrodinger, etc

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Senior Computational Biologist – Multiomics

Position Description

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Computational Biologist – Multiomics who are excited to work as a core member of a team focused on the discovery and validation of novel candidate biologics for tissue regeneration and increased stem cell activity.

The computational biologist will be responsible for driving project-specific lead discovery and prioritization by extracting meaningful biological insights from large, complex omics datasets and integrating the results into Juvena Therapeutics’ growing in-house knowledge ecosystem.

They will develop and apply creative, leading-edge approaches in bioinformatics, biostatistics, and machine-learning to integrate proprietary high throughput in vitro screening and in vivo verification assays, protein/gene annotation and pathway databases, ontologies, and publicly available omics datasets. Predictive modeling will be applied to enhance the efficiency of lead therapeutic drug screening and design.

The position is full-time starting as early as possible. This is the perfect opportunity for someone interested in the exciting and fast-paced environment of a startup company looking to make a difference in human health and healthspan.

Position Requirements

  • Bring to the Discovery team your expertise in a) identification, curation, integration, and analysis of multiomics data, b) statistical analysis and visualization of complex data relationships driving lead discovery and validation, and c) statistical and machine-learning based predictive modeling to make strategy recommendations.
  • Develop and apply computational models to enhance the efficiency of candidate biologics screening for increased stem cell activity from prototype to scale deployment.
  • Work cross-functionally to create the best possible pipeline of candidate therapeutics and the tools to scale out efficiently across multiple indications.
  • Improve efficiency by automating data extractions, analyses, and reporting;
  • Manage Google Cloud and AWS resources connected to relevant projects;
  • Other scientific tasks as required.
  • Actively survey the forefront of published methods and resources for your field and internalize key aspects to the company

Qualifications

This position is a great fit if you have/are:

  • M.S./PhD in Biostatistics, Bioinformatics, Computer Science + Biological research, or other related disciplines involving both biology and computational data analysis, with 1-4 years of post-graduate experience
  • Demonstrated mastery of both computational analysis and biology with publications, co-inventorships, or other impressive achievements
  • Highly communicative. Effective communicator verbally, in writing, and in presentations to both expert and novice audiences
  • Self-Starter – Can work independently and/or collaboratively with scientists to make appropriate and timely decisions to meet deadlines on experiments and projects
  • Strong foundational knowledge and experience with biological data, particularly with methods generating large scale  omics data sets (e.g. epigenomics, genomics, transcriptomics, proteomics)
  • Expertise in computational multi-omics analysis integrating multiple data types including large omics datasets such as single-cell RNAseq studies, ontologies, and pathways/networks.
  • Experience in statistics and predictive modeling such as Bayesian statistics, linear and non-linear modeling, multivariate analysis, network analysis, machine learning, etc.
  • Demonstrated expertise in a scripting language (e.g. Python)
  • Demonstrated expertise in statistical computing language (e.g. R or Python)
  • Demonstrated expertise in cloud computing systems – experience with Google Cloud and AWS resources is a plus
  • Familiarity with pharmaceutical R&D is a plus.
  • Industry or startup R&D experience is a plus.

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

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Hanadie Yousef, PhD

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Dr. Hanadie Yousef is a scientist, aging biology expert and the co-founder and CEO of Juvena Therapeutics, a biopharma startup developing protein-based therapeutics to promote tissue regeneration and increase healthspan to prevent, reverse, and cure degenerative diseases.

For over 18 years, Dr. Yousef performed biomedical research in both academia and industry. She studied mechanisms that underly brain and muscle aging, including adult stem cell decline, inflammation, and fibrosis associated with aging and multiple degenerative diseases. She elucidated age-associated protein signaling changes systemically and locally in tissues that lead to loss of tissue homeostasis and the onset of degenerative diseases. Dr. Yousef’s discoveries led to several novel drug targets and methods for tissue rejuvenation. Her research was supported by multiple fellowships and grants that include the NIH, NSF, and SPARK and has led to numerous issued and pending patents. Her research has been highlighted in high-profile publications including Nature Medicine, Cell Reports, and others on mechanisms of aging and methods for tissue rejuvenation, particularly in the brain and muscle. Dr. Yousef’s key discoveries laid the foundation of Juvena Therapeutics’ venture-backed, drug discovery and preclinical development platform.

Since Juvena’s launch in mid-2018, Dr. Yousef and her team have translated those key discoveries into a proprietary pro-regenerative protein library and validated their potency on multiple tissue types, with several issued and pending patents. They built a machine learning-enhanced drug discovery and preclinical development platform to enable a pipeline of drug candidates for multiple age-related and rare diseases. The platform has enabled the identification, extensive preclinical validation, and lead optimization of 3 novel drug candidates that enhance muscle regeneration, function, and reduce frailty, with several additional discovery candidates for degenerative diseases.

Dr. Yousef earned her B.S. in Chemistry with a Spanish minor, summa cum laude from Carnegie Mellon University, a PhD in Molecular and Cell Biology from UC Berkeley as an NSF graduate research fellow, pursued a 5-year postdoctoral fellowship in Neurology at Stanford School of Medicine as an NIH fellow and SPARK scholar, and conducted research and development for Regeneron and Genentech.

PhD Training (2008-2013)

During her graduate studies at UC Berkeley, Dr. Yousef studied protein signaling mechanisms underlying adult stem cell decline with aging and developed methods for tissue rejuvenation in brain and muscle in the world-renowned Schaffer and Conboy labs. Her discoveries that a specific subfraction of human embryonic stem cell-secreted proteins enhance aged muscle regeneration and human myogenesis and enhance the activity and survival of neural stem cells and cortical neurons laid the foundations of Juvena’s proprietary rejuvenating protein library and discovery platform.

Achievements: First author of 4 publications outlining mechanisms underlying stem cell decline with age; developed methods for brain and muscle tissue rejuvenation leading to 3 issued patents, and secured an NSF graduate research fellowship (2009-2013).

Postdoctoral Fellowship (2014-2018)

During her tenure at the Stanford School of Medicine in the world-renowned Wyss-Coray lab, Dr. Yousef elucidated molecular and cellular mechanisms that contribute to both a decline in brain function with aging and the onset of neurodegenerative diseases, with a focus on understanding the interactions between aged blood and the blood-brain barrier. Her first author discoveries on a mechanism underlying inhibition of brain function by aged blood through the blood-brain barrier were published in Nature Medicine (May 2019) and Cell Reports (March 2020). Dr. Yousef won two consecutive SPARK grants to translate her discovery into the clinic for neurodegeneration and vascular dementia and has an issued patent from Stanford. In addition to her research, Dr.Yousef spearheaded collaborations across departments that led to numerous other discoveries, grants, and co-authorship on multiple high-profile publications.

Achievements: Nature Medicine (May 2019), first author; Cell Reports (March 2020), co-first author; multiple co-authorships in top journals including Nature; issued patent No. 10,947,311; NIH F32 postdoctoral fellowship (2015-2018), SPARK scholar and grant recipient (twice).

While at Stanford, 2017, Dr. Yousef co-founded Juvena Therapeutics, Inc., to pursue her dream to build an innovative biopharmaceutical company that develops novel protein-based medicines that promote tissue regeneration and increase healthspan for age-related and rare degenerative diseases.

Learn More about Hanadie

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Jeremy O’Connell, PhD

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As CSO at Juvena Therapeutics, Dr. O’Connell guides R&D strategy and strategic level experimental design and structure for all milestones. He personally leads the proteomics division of Juvena Therapeutics R&D.

Jeremy O’Connell is a proteomics and systems biology expert with numerous publications, a PhD from UT Austin, a postdoc at Harvard, and experience leading research teams.

During his postdoctoral fellowship at Harvard Medical school in the lab of Steven Gygi he leveraged immense proteomics datasets to build several machine learning classifiers focusing on predicting protein-protein interactions within the ubiquitin system. He has spearheaded research projects in multiple tier one research institutions, including Harvard and Stanford, employing a combination of mass spectrometry, high throughput imaging, computational approaches as demonstrated in his 13 publications to date, several fellowships, and awards.

Learn more about Jeremy

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Jim McGuire, PhD

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Jim McGuire is a veteran of the biotech and pharma industry where he has led multiple drug discovery groups and projects. He earned his PhD in Organic Chemistry from the University of Illinois at Urbana-Champaign and followed with a postdoc at the University of Copenhagen. He went on to work with small molecule ADME at H. Lundbeck A/S and protein biomarkers at Ciphergen, Inc. followed by 15 years at Novo Nordisk A/S, where he focused on biologics in the cardiometabolic space with an increasing level of people and project responsibility. He helped lead 13 projects from discovery to development including a number of GLP-1 therapies. In addition he was part of bringing semaglutide to the market as the once-weekly injectable Ozempic. He was most recently an Executive Director of Translational Research at Catalyst Biosciences where he led their discovery efforts and helped bring two complement programs into development. He has co-authored 23 peer-reviewed articles and four patents.

Learn more about Jim

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Eddie Moler, PHD

Eddie Moler joined Juvena Therapeutics in June 2022, bringing over 20 years of experience leading pharmaceutical and clinical diagnostics R&D, data-science/algorithm/software intensive platform development, gene-target and biomarker discovery and validation, establishing and scaling high-performing data-science & software teams, and collaboration management.

Previously, Eddie led Quest Diagnostics’ Bioinformatics organization, leading the development and launch of dozens of advanced clinical genomic diagnostic tests while more than quadrupling the size of the team across multiple sites. He has led clinical/biological research projects and the development of production-scale clinical and research platforms at Quest Diagnostics, GE Healthcare, Tethys Bioscience, Novartis, and the US Department of Energy.

He has published over 50 peer-reviewed papers including clinical and molecular medicine, population health, and health economics, and has 7 issued patents on clinical risk algorithms, biomarkers, automated histopathology image analysis, drug targets, and discovery technology. Eddie received a PhD in Chemistry from UC Berkeley and a BS in Chemistry from Texas A&M University.

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Stephen Juelsgaard, DVM, JD

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Stephen Juelsgaard is the former executive vice president, secretary and chief compliance officer of Genentech, Inc. His career at Genentech spanned 24 years. In that role, Dr. Juelsgaard reported to Genentech’s CEO, Art Levinson, and was responsible for Genentech’s Corporate Law, Intellectual Property, Government Affairs (Federal and State), Human Resources, and Healthcare Compliance groups, as well as the Business Services group, which included Strategic Facilities Planning, Corporate Security, Business Continuity, and Environment, Health & Safety. He also chaired Genentech’s Capital Governance Committee, which oversaw major capital expenditures at the company, and was a member of Genentech’s executive committee, the most senior management committee at the company. He had oversight responsibility for more than 600 employees and an annual budget of approximately $250 million.

Juelsgaard joined Genentech in 1985 as corporate counsel and became senior corporate counsel in 1989. In 1992 he became vice president, Corporate Law and in 1994 was named general counsel, a role he served in through 2007. Juelsgaard was named secretary to the Board of Directors in 1997 and a senior vice president in 1998. In 2002, he was appointed executive vice president, in 2005 was named chief compliance officer, and in 2007 he became responsible for oversight of the Government Affairs group. Juelsgaard was the company’s representative on the board of directors of the California Healthcare Institute from 2005 until 2009.

Prior to joining Genentech, Juelsgaard was an associate for three years with the law firm Wilson Sonsini Goodrich & Rosati in Palo Alto, California. Prior to attending law school, Juelsgaard was engaged for three years in a private veterinary medical practice.

Juelsgaard currently teaches at the Stanford Law School. He currently serves on the board of directors of Altrubio, an antibody-drug conjugate company targeting a variety of autoimmune and immune-mediated inflammatory diseases. He is a past member of the board of directors of Ivivi Health Sciences LLC, a private medical device company, and of Rio Grande Neurosciences, Inc., a private company engaged in the development of pulsed electromagnetic field technology as well as transcranial electrical stimulation and transcranial magnetic stimulation technologies.

Juelsgaard received his Doctor of Veterinary Medicine degrees from Iowa State University in 1972 and a Masters Degree in Veterinary Clinical Sciences in 1975 from Iowa State University, and in 1982 he received a law degree from Stanford Law School.

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