Back to Careers

Principal Data Scientist – Drug Discovery & Development

Position Description

Juvena Therapeutics, Inc. is a regenerative medicine biotech startup inviting applicants for Principal Data Scientist – Drug Discovery & Development, who are excited to work as a core member of a team focused on the discovery and validation of novel candidate disease-modifying biologics that promote tissue regeneration by inducing tissue-specific rejuvenating phenotypes. We are discovering and developing various biologics that can promote disease-modifying phenotypes such as increasde stem cell activity, reduced chronic or localized inflammation, reduced fibrosis, improved differentiation, or increased mitochondrial function and metabolism.  

The Principal Data Scientist, reporting to the Head of Data Science and working closely with lab+computational scientists and other researchers, will drive the discovery and development of new therapeutic agents by providing leadership in statistical design, computational analysis, and predictive modeling throughout the drug discovery and development process, including algorithms for predicting disease-modifying biologic candidates & biomarkers, in vitro and in vivo experiment design and analysis, developing and automating assay read-out models & statistical QC analyses, and supporting regulatory approval (IND, NDA, etc.). The successful candidate will support pre-clinical and clinical activities related to regulatory interactions and approval as required. The Principal Data Scientist will also be a key contributor to Juvena Therapeutics’ growing in-house knowledge ecosystem (JuvNET), and developing tools and applications that extends to scientists the use JuvNET across organs, diseases, proteins, and pathways.

The position is full-time starting as early as possible. This is the perfect opportunity for someone interested in the exciting and fast-paced environment of a startup company looking to make a difference in human health and healthspan.

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies, muscle atrophy, injury, osteopathies, and new programs targeting additional degenerative diseases affecting other human organs. Since our launch in mid-2018, Juvena has discovered and validated 22 hits for neuromuscular, skeletal, and metabolic diseases. Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

Juvena Therapeutics has secured >$47M in venture capital, NIH, and CIRM funding to develop their top lead to a clinical-stage investigational new drug, to build their stem cell secretome database, and to leverage their discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across inflammatory, cardiometabolic and hepatic therapeutic areas. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Major Responsibilities

  • Bring to the Juvena Team your expertise in:
    • statistical analysis and visualization of complex data relationships driving lead discovery and validation
    • statistical leadership in clinical & pre-clinical drug/biomarker development projects
    • Feature identification, algorithm development, and model selection approaches in the presence of potential bias, over-fitting, and other factors that impact generalizability of model performance
    • Establishing analytical pipelines, packages, & tools that drive best-practices and shared codebase development
  • Support pharmaceutical co-development projects and associated business development objectives
  • Support pre-clinical and clinical activities related to regulatory meetings and submissions
  • Develop and apply computational models to enhance the efficiency of candidate biologics identification, screening, and pre-clinical validation
  • Work cross-functionally to create the best possible pipeline of candidate therapeutics and the tools to scale out efficiently across multiple indications
  • Improve efficiency by automating data extractions, analyses, and reporting; 
  • Manage Google Cloud and AWS resources connected to relevant projects; 
  • Other tasks as required.
  • Actively survey the forefront of published methods and resources for your field and internalize key aspects to the company

Position Requirements and Experience

This position is a great fit if you have/are:

  • Ph.D in Biostatistics, Bioinformatics, a Biological field, or other related disciplines involving computational biological data analysis
  • 10+ years of experience applying computational & statistical analyses to Life Sciences R&D objectives such as biomarker discovery and development, early target discovery, pre-clinical & clinical study design, PK/PD, toxicogenomics, MOA studies, etc.
  • Demonstrated mastery of both computational-statistical analysis and biology with publications, co-inventorships, or other impressive achievements
  • Experience integrating and analyzing multi-omic data
  • Highly communicative – Effective communicator verbally, in writing, and in presentations to both expert and novice audiences
  • Highly motivated – loves working collaboratively with scientists, pursue delivering objective of analysis/tool to meet deadlines on experiments and projects
  • Demonstrated expertise in statistical computing language (e.g. R and/or Python)
  • Experience with cloud computing systems is a plus (e.g. GCP, AWS)
  • Industry and startup R&D experience is a plus

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

Back to Careers

Fengling Liu, PhD

linkedin-icon-green

Dr. Fengling Liu joined Juvena as a Director of Protein Science in July 2022. Dr. Liu brings over 10 years of industry experience developing multiple biologics. Since 2010 she served as the Protein Biochemistry lead or group lead of Protein Science in multiple biotechs in the bay area including Medimmune (AstraZeneca), Relypsa, Atreca and Arcus Biosciences.

Her protein science-focused research spanned target identification/confirmation, lead optimization, protein purification and engineering to support vaccine development, small molecule and antibody drug discovery in infectious disease and Immuno-Oncology. She was trained in Biochemistry and Structure Biology during her PhD at Georgia State University. She studied the molecular basis of HIV protease drug resistance through enzyme kinetics and X-ray crystal structures.  She solved over a dozen super high resolution crystal structures of HIV/drug complexes and discovered a novel drug resistance mechanism.

During her postdoc in the lab of Professor Ted Jardetzky in the Structural Biology Department at Stanford Medical School, Dr. Liu studied human viral glycoprotein interactions to discover viral entry inhibitors.

Besides her passion for science and technology, Fengling also enjoys gardening and hiking with family and friends.

Learn more about Fengling

LinkedIn

Back to Careers

Munir Yousef, MS

linkedin-icon-green

Munir Yousef joined Juvena Therapeutics in July 2022 as a bioinformatics analyst to contribute to Juvena’s growing platform by developing robust data analysis pipelines for their in silico protein drug discovery platform.

After realizing his passion for data-driven discovery of solutions to real world problems, Munir obtained his Masters degree in Applied Data Science from Syracuse University.

Before officially joining the team, Munir worked as a data science consultant and helped develop internal data analysis and visualization tools to support Juvena’s growing R&D platforms.

Learn more about Munir Yousef

LinkedIn

Back to Careers

Senior Research Associate/Associate Scientist

Bioanalytical Assay Development

Position Description

We are seeking a talented Senior Research Associate or Associate Scientist with experience in bioanalytical assay development to be an integral part of our drug discovery platform expansion. We are searching for an individual who is excited to perform bioanalytical assays in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases. Reporting to the Director of Protein Science, this individual will be an integral member of the expanding protein science team to increase our pipeline of state-of-the-art biologics. The ideal candidate will have industry experience in a drug discovery and early development setting and have been involved in lead candidate identification, selection, and IND-enabling studies for biologics.

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies, muscle atrophy, injury, osteopathies, and new programs targeting additional degenerative diseases affecting other human organs. Since our launch in mid-2018, Juvena has discovered and validated 22 hits for neuromuscular, skeletal, and metabolic diseases. Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

Juvena Therapeutics has secured >$47M in venture capital, NIH, and CIRM funding to develop their top lead to a clinical-stage investigational new drug, to build their stem cell secretome database, and to leverage their discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across inflammatory, cardiometabolic and hepatic therapeutic areas. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Major Responsibilities

  • Develop, perform, and optimize bioanalytical assays for Juvena’s lead molecules
  • Conduct qualification and validation of bioanalytical assays following regulatory guidelines
  • Maintain accurate, timely, and detailed notebooks of all experimental work in accordance with SOPs
  • Assist in equipment purchase, maintenance, and calibration
  • Reagent sourcing, storage, inventory, preparation        
  • Communicate scientific data internally and externally
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation
  • Maintain flexibility in supporting multiple discovery and preclinical projects as the company grows

Position Requirements and Experience

  • BS/MS degree in cell biology, molecular biology, biochemistry, or a related field with 2-5 years of industry experience in a drug discovery environment
  • Title and compensation commensurate with experience
  • Demonstrated ability to support biologic-based projects from lead generation to optimization, candidate selection, and IND filing 
  • Documented experience with bioanalytical assay development and troubleshooting

Preferred Qualifications

  • Experience with immunoassay development and statistical data analysis, such as ELISA, ADA assays, drug potency assays, and biomarker assays.
  • Experience with mammalian cell culture is preferred 
  • Knowledge of protein engineering, biophysical methods, and basic immunology
  • Strong organizational and communication skills
  • Detail oriented with a desire to obtain high quality data
  • Willingness to learn and enjoy working as a team

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays

Apply Now

To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

Back to Careers

CSO and Co-Founder Dr. Jeremy O’Connell presents at FASEB Industry Panel Jul. 2022

Back to Careers

Head of Translational Biology

Position Description

Juvena Therapeutics is seeking a talented scientific strategist and experienced people leader to lead their Discovery platform expansion and Nonclinical Development of lead candidates. We are searching for individuals who are excited to work as a leader in an intimate and small team focused on the discovery, preclinical validation, and clinical translation of novel biologics for chronic and rare degenerative diseases across multiple therapeutic areas such as inflammatory, hepatic, and metabolic related diseases. This position would oversee the R&D strategy. This person would oversee the discovery, phenotype-based screening, target validation, and protein engineering efforts at Juvena, managing the secretome library creation, human phenotypic screening assays, bioanalytical assays, and preclinical rodent disease model studies.

The Head of Translational Biology will work closely with department heads across data science, preclinical, and clinical teams to expand Juvena’s platform for unraveling secretome biology to develop novel disease-modifying biologics. The Head of Translational Biology will work collaboratively to establish a robust protein drug screening platform and preclinical biologics pipeline for multiple indications, driving hit generation, lead selection and indication selection, and development of pre-IND data packages. The Head of Translational Biology will support grant applications, reports, and manuscript preparations. Reporting to the CSO, the Head of Translational Biology will be an integral member of the Scientific Leadership Team and will be involved in all Juvena’s programs plus be involved in establishing external R&D partnerships with academic institutions and technology partners. The candidate should have industry experience in a drug discovery and development setting and have managed or been involved in high throughput screening, lead and indication selection, and IND-enabling studies for biologics.

Company Summary

Juvena Therapeutics is on a mission to discover and develop biologics for rare and chronic degenerative diseases by mining the secretomes of human pluripotent stem cells through a machine learning (ML)-enhanced platform. Juvena’s approach integrates proteomics, transcriptomics and imaging with phenotypic human in vitro disease model screening and extensive preclinical validation to mine stem cell secretomes as a rich source of new medicines for chronic and rare diseases. We are advancing leads for muscular dystrophies, muscle atrophy, injury, osteopathies, and new programs targeting additional degenerative diseases affecting other human organs. Since our launch in mid-2018, Juvena has discovered and validated 22 hits for neuromuscular, skeletal, and metabolic diseases. Juvena is advancing a lead program for Myotonic Dystrophy Type 1, a rare autosomal dominant, progressive muscle-wasting disease.

Juvena Therapeutics has secured >$47M in venture capital, NIH, and CIRM funding to develop their top lead to a clinical-stage investigational new drug, to build their stem cell secretome database, and to leverage their discovery platform to rapidly identify and validate novel protein-based drug candidates for multiple rare and chronic diseases across inflammatory, cardiometabolic and hepatic therapeutic areas. At Juvena we embrace a diversity of backgrounds, experience and approaches that all combine to lead us to world-class scientific results in an inclusive environment.

Major Responsibilities

  • Lead the indication selection and prioritization efforts to identify therapeutic areas with strong clinical and regulatory paths to clinic for Juvena to expand its protein drug discovery and preclinical development platform 
  • Lead efforts to expand Juvena’s platform screening capabilities across multiple organ model systems, integrating the latest in bioinformatics, computational and machine learning approaches for in silico, in vitro, and in vivo screening, ensuring the discovery team is working collaboratively with the data science team to advance the platform and support hit generation, target identification, and MOA studies.  
  • Identify and source preclinical and clinical KOLs to advise Juvena for therapeutic areas of interest 
  • Contribute to go/no go decisions for lead selection, lead optimization and preclinical development paths                            
  • Develop and progress projects from hit generation, lead selection, target validation, lead optimization, pharmacology, and through to the initiation of IND-enabling studies for biologics, internally and externally via CRO project management across all phases of Juvena’s discovery and development
  • Collaborate with Research, Pharmacology, Bioanalytical, Engineering, Manufacturing, and Quality/Reg CMC colleagues across the company and externally to advance Juvena’s platform and pipeline
  • Communicate scientific data internally and externally, authoring/reviewing study reports and regulatory documentation, contributing to high impact scientific manuscripts, identifying & managing external research collaborations, and engaging with scientific advisors and consultants                       
  • Provide strategic and scientific leadership as part of cross-functional research teams
  • Serve as an internal subject matter expert for the design, execution, and interpretation of discovery and pharmacology experiments
  • Manage, guide, and mentor the discovery and protein engineering teams. 
  • Interact with and manage the in vivo pharmacology team to support target validation and efficacy assessment of potential developmental candidates. Support the planning of in-house and outsourced pharmacology activities
  • Provide support and guidance for in vitro and in vivo assays that may be conducted with external academic/industry collaborators and with CROs
  • Present at group, company, and external meetings/conferences
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation
  • Keep current with clinical advances in the company’s therapeutic interest areas
  • Flexible support of multiple discovery, platform development and preclinical projects as the company grows

Position Requirements and Experience 

  • PhD with 10+ years of industry experience in drug discovery and development setting
  • Demonstrated ability to advance programs from discovery through lead identification and IND with biologics such as fusion proteins, bispecifics, antibody or antibody drug conjugate molecules, preferably in the regenerative medicine space, and inflammatory, cardiovascular, metabolic disease areas  
  • Deep understanding of bioinformatics and machine learning applications for drug discovery, target identification and validation, lead selection, lead optimization, and in vivo pharmacology and strong track record of driving research stage programs into the clinic
  • Experience in GMP/GLP documentation and IND filing
  • Established track record of leadership in discovery and preclinical development projects
  • Established record of leading cross-functional discovery and development teams with both internal and external partners in multiple IND-enabling areas including protein engineering, antibody discovery, bioanalytical assay development, safety/toxicology and pharmacology 
  • Experience interfacing with multiple key stakeholders in a dynamic environment to enable real-time prioritization
  • Strong communication skills
  • Highly self-motivated and driven to succeed 
  • Prior success with research in a hands-on, highly collaborative growth environment
  • The ability to work effectively both independently and as part of multidisciplinary team in a fast-paced environment
  • Organized, detail-oriented, and a self-starter who continuously seeks innovative solutions
  • Intellectually curious; eager to brainstorm and test potential answers to tough technical questions
  • Works well in fast-paced startup environment
  • Eager to bring proven lab-based leadership qualities to a growth-oriented direct management position

Preferred Qualifications

  • Successful track record of target id, validation, lead candidate selection, and optimization towards target product profiles through to developmental candidate designation
  • Successful track record of indication selection and prioritization analyses 
  • Successful track record of managing IND-enabling studies with significant contribution to FDA-approved INDs 
  • Experience working cross-functionally with protein engineering and CMC 
  • Experience with pre-commercial process and analytical development
  • Experience with process design and familiarity with scale-up and GMP manufacturing considerations 

Compensation and Benefits

  • Competitive salary, annual bonus and stock options
  • Health/Dental/Vision insurance
  • Paid vacation and holidays 

Apply Now


To apply for this position please complete the form below. Once the form is complete, email your CV and Cover Letter to apply@juvenatherapeutics.com with the title of the position as the subject line.  

Back to Careers

Pallavi Kompella, PhD

linkedin-icon-green

Dr. Kompella joined Juvena Therapeutics in July 2022 to support the validation and lead optimization of protein-based therapies in vivo and new mouse model development.

As a trained pharmacologist, Dr. Kompella has extensive experience in contributing to early-stage drug discovery. She has designed and managed several hypothesis-driven mechanistic studies and established preclinical mouse models for lead optimization and toxicological risk assessment of potential small molecule drugs across several therapeutic areas.

After receiving her Bachelor’s and Master’s degree in Biotechnology from India, she worked for 8 years at various drug discovery organizations in India and the U.S. Dr. Kompella received her Ph.D. in Pharmacology and Toxicology from the University of Texas at Austin (UT Austin) where she investigated the underlying molecular mechanisms of how diet-induced obesity influences DNA damage and repair and contributes to cancer development. Dr. Kompella has been awarded multiple graduate fellowships from UT Austin and the American College of Toxicology. She is also the recipient of an American Foundation for Pharmaceutical Education (AFPE) pre-doctoral research fellowship. 

Before joining Juvena Therapeutics, Dr. Kompella was a Fulbright U.S. Postdoctoral Scholar at the Biomedical Research Institute of Malaga (IBIMA) in Malaga Spain. At IBIMA, she studied the role of obesity-mediated epigenetic modification of DNA damage repair protein OGG1 in visceral adipose tissue from patients with obesity.


Besides research, she loves doing science outreach and going on hikes with friends and family.

Learn more about Pallavi

LinkedIn

Back to Careers

Jeff Welch

linkedin-icon-green

Jeff Welch has over 30 years of CMC experience in the process development, GMP manufacturing and facilities, and regulatory documentation.

In Jeff’s most recent role as a consultant he has had responsibility for authoring and reviewing regulatory filing sections related to process development and product characterization.

Over the past decade Jeff has focused on his role as a senior director for drug substance (DS) process development and director over process engineering and operations for a specialty pharmaceutical company working in biologics and vaccines and as a CDMO organization.

Jeff has also served as a project manager for large scale manufacturing and technology transfer projects and filled the DS team leader role. After a lead role in engineering and construction, he served as a senior manager over the start up effort for a stainless steel cell culture facility (1600 L scale), where he hired and managed personnel and led a 7-day-a-week cGMP manufacturing operation for the upstream portion.

In his early career he participated in design of a multi-product manufacturing facility and after start-up performed process fit and technology transfer activities for several microbial, yeast and cell culture products.

Learn more about Jeff Welch

LinkedIn