RAMI JAAFAR, PHD
IN VIVO MUSCLE BIOLOGIST
Dr. Jaafar has a life science PhD with 13 years of expertise in muscle physiology, diabetes and age-related metabolic diseases. He joined Juvena Therapeutics in August 2019 as the resident in vivo biologist to lead the validation of Juvena’s key protein factors in preclinical models.
Dr. Jaafar’s research has focused on muscle regeneration and differentiation. He has numerous publications, and in particular, published 3 peer-reviewed articles exploring multiple aspects of muscle function and strategies that promote muscle differentiation and evaluate muscle strength.
Dr. Jaafar received his PhD in biochemistry from the engineering school INSA de Lyon in France followed by 1 year of postdoctoral training at the Cancer Research Center in Lyon. During this training, Dr. Jaafar studied the signaling pathway responsible for the reprogramming of endocrine cells in the context of neuroendocrine tumors and type 2 diabetes.
Before joining Juvena, Dr. Jaafar completed 5 years of postdoctoral training at the University of California, San Francisco (UCSF). At UCSF, he studied the age-related maturation of pancreatic beta cells using optimized high throughput sequencing screening strategies. He identified an intriguing concept of pancreatic beta cell maturation that occurs in the context of a fundamental switch from mTORC1 to AMPK signaling. His work was published in the Journal of Clinical investigation and was featured in UCSF News and Media. In addition, Dr. Jaafar is preparing a new publication where he shows that the mechanisms maintaining the integrity of the DNA are compromised in type 2 Diabetes, therefore highlighting the DNA repair and DNA damage response as a potential therapeutic target for type 2 diabetic patients.
In his spare time, Dr. Jaafar enjoys traveling and spending way too much money on fitness studios like Barry’s Bootcamp and SoulCycle.