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Hanadie Yousef is a trained stem cell biologist and neurobiologist with a focus on the mechanisms of aging, with pending and issued patents, several publications, a BS from Carnegie Mellon University (CMU), a PhD from UC Berkeley, a 4-year postdoctoral fellowship at Stanford School of Medicine, experience leading research teams, and has worked in R&D at Regeneron and Genentech.    Yousef began doing biomedical research at the age of 16, when she interned locally at a pharmaceutical company in New York where she grew up, Regeneron, to conduct research on gene therapy and cancer. It was at this time that Yousef fell in love with drug discovery and development and knew she wanted to dedicate the rest of her life to this pursuit. She skipped a grade and attended CMU to study chemistry and continue her passion in scientific research. She returned to Regeneron to continue her research during winter and summer internships for 5 years (2003-2008). During her undergraduate studies at CMU, Yousef did a research honors thesis in the Kaminski lab at the University of Pittsburgh Medical Center, where she elucidated molecular mechanisms driving idiopathic pulmonary lung fibrosis.    In graduate school in the Schaffer and Conboy labs at UC Berkeley (2008-2013), Dr. Yousef studied the role of adult stem cells in the biology of aging and developed methods for tissue rejuvenation in brain and muscle. She published 4 first-author papers, a research perspective,and has an issued patent and a patent application based on her discoveries.
 
 

RAMI JAAFAR, PHD
IN VIVO MUSCLE BIOLOGIST

Dr. Jaafar has a life science PhD with 13 years of expertise in muscle physiology, diabetes and age-related metabolic diseases. He joined Juvena Therapeutics in August 2019 as the resident in vivo biologist to lead the validation of Juvena’s key protein factors in preclinical models.

Dr. Jaafar’s research has focused on muscle regeneration and differentiation. He has numerous publications, and in particular, published 3 peer-reviewed articles exploring multiple aspects of muscle function and strategies that promote muscle differentiation and evaluate muscle strength.

Dr. Jaafar received his PhD in biochemistry from the engineering school INSA de Lyon in France followed by 1 year of postdoctoral training at the Cancer Research Center in Lyon. During this training, Dr. Jaafar studied the signaling pathway responsible for the reprogramming of endocrine cells in the context of neuroendocrine tumors and type 2 diabetes.

Before joining Juvena, Dr. Jaafar completed 5 years of postdoctoral training at the University of California, San Francisco (UCSF). At UCSF, he studied the age-related maturation of pancreatic beta cells using optimized high throughput sequencing screening strategies. He identified an intriguing concept of pancreatic beta cell maturation that occurs in the context of a fundamental switch from mTORC1 to AMPK signaling. His work was published in the Journal of Clinical investigation and was featured in UCSF News and Media. In addition, Dr. Jaafar is preparing a new publication where he shows that the mechanisms maintaining the integrity of the DNA are compromised in type 2 Diabetes, therefore highlighting the DNA repair and DNA damage response as a potential therapeutic target for type 2 diabetic patients.

In his spare time, Dr. Jaafar enjoys traveling and spending way too much money on fitness studios like Barry’s Bootcamp and SoulCycle.